Document Detail


Superselective cerebral arterial infusion of BCNU in high-grade glioma: the radiologist's point of view.
MedLine Citation:
PMID:  2971050     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-two patients suffering from high-grade glioma were candidates for superselective cerebral arterial infusion of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) after surgery and radiation therapy. There were 74 catheterizations using an 8-French guiding catheter through which a 2.5-French balloon catheter was placed into the main arterial trunk feeding the tumor. Eleven procedures were abandoned because of arterial spasm with a transient neurological deficit or because of prolonged catheterization time. Sixty-three infusions of BCNU were done, each lasting three hours. Eighty-one percent of patients showed stabilization or improvement on computed tomographic (CT) scans five weeks after treatment. We thus demonstrate the safety of supraophthalmic catheterization, the feasibility of prolonged catheterization, and the relative effectiveness of low doses of BCNU infused over a long period of time in the treatment of cerebral gliomas.
Authors:
S Fontaine; J Théron; D Melanson; J G Villemure; J Emrich; J Raymond; R Ethier
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes     Volume:  39     ISSN:  0846-5371     ISO Abbreviation:  Can Assoc Radiol J     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-17     Completed Date:  1988-10-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8812910     Medline TA:  Can Assoc Radiol J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  178-81     Citation Subset:  IM    
Affiliation:
Montreal Neurological Hospital and Institute, Quebec.
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MeSH Terms
Descriptor/Qualifier:
Brain Neoplasms / drug therapy*,  radiography
Carmustine / administration & dosage*,  therapeutic use
Catheterization / methods
Cerebral Angiography
Cerebral Arteries
Female
Glioma / drug therapy*,  radiography
Humans
Infusions, Intra-Arterial / methods*
Male
Middle Aged
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
154-93-8/Carmustine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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