Document Detail

Superprecipitation of hybrid actomyosin containing pathologic actin from failing hearts of adults and infants.
MedLine Citation:
PMID:  4029605     Owner:  NLM     Status:  MEDLINE    
Superprecipitation (SP) of artificial actomyosin, obtained by hybridization of Straub actin from the human myocardium with myosin of normal animal hearts was studied. Actin was prepared from the myocardium of persons who died of congestive heart failure and various non-cardiac diseases, as well as of infants whose death resulted from toxic pneumonia complicated or not with heart failure. It was shown that, in the control hybrid actomyosin, the substitution of normal Straub actin by that from the failing heart resulted in decrease of both the rate and extent of SP. The conclusion was made that both changes in myosin properties and Straub actin underlie the reduced contractility of the myofibrillar protein system in acute and congestive heart failure.
N V Karsanov; G I Nizharadze; M P Pirtskhalaishvili; J J Eristavi; O Sh Khundadze; L E Kuchava; I V Pavlenishvili; L V Shengelia
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  General physiology and biophysics     Volume:  4     ISSN:  0231-5882     ISO Abbreviation:  Gen. Physiol. Biophys.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-10-10     Completed Date:  1985-10-10     Revised Date:  2008-11-24    
Medline Journal Info:
Nlm Unique ID:  8400604     Medline TA:  Gen Physiol Biophys     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  417-23     Citation Subset:  IM    
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MeSH Terms
Actins / isolation & purification*,  metabolism
Actomyosin / isolation & purification*,  metabolism
Heart Failure / metabolism*
Myocardium / metabolism*
Reference Values
Reg. No./Substance:
0/Actins; 9013-26-7/Actomyosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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