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Superparamagnetic iron oxide polyacrylic acid coated γ-Fe(2)O(3) nanoparticles does not affect kidney function but causes acute effect on the cardiovascular function in healthy mice.
MedLine Citation:
PMID:  23142473     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study describes the distribution of intravenously injected polyacrylic acid (PAA) coated γ-Fe(2)O(3) NPs (10mgkg(-1)) at the organ, cellular and subcellular levels in healthy BALB/cJ mice and in parallel addresses the effects of NP injection on kidney function, blood pressure and vascular contractility. Magnetic resonance imaging (MRI) and transmission electron microscopy (TEM) showed accumulation of NPs in the liver within 1h after intravenous infusion, accommodated by intracellular uptake in endothelial and Kupffer cells with subsequent intracellular uptake in renal cells, particularly the cytoplasm of the proximal tubule, in podocytes and mesangial cells. The renofunctional effects of NPs were evaluated by arterial acid-base status and measurements of glomerular filtration rate (GFR) after instrumentation with chronically indwelling catheters. Arterial pH was 7.46±0.02 and 7.41±0.02 in mice 0.5h after injections of saline or NP, and did not change over the next 12h. In addition, the injections of NP did not affect arterial PCO(2) or [HCO(3)(-)] either. Twenty-four and 96h after NP injections, the GFR averaged 11.0±0.8 and 13.0±0.4mlmin(-1)g(-1), respectively, values which were statistically comparable with controls (14.0±0.2 and 14.0±0.6mlmin(-1)g(-1)). Mean arterial blood pressure (MAP) decreased 12-24h after NP injections (111.1±11.5 vs 123.0±6.1min(-1)) associated with a decreased contractility of small mesenteric arteries revealed by myography to characterise endothelial function. In conclusion, our study demonstrates that accumulation of superparamagnetic iron oxide nanoparticles does not affect kidney function in healthy mice but temporarily decreases blood pressure.
Authors:
Nina K Iversen; Sebastian Frische; Karen Thomsen; Christoffer Laustsen; Michael Pedersen; Pernille B L Hansen; Peter Bie; Jérome Fresnais; Jean-Francois Berret; Erik Baatrup; Tobias Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-7
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  -     ISSN:  1096-0333     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Zoophysiology, Department of Biological Sciences, Aarhus University; Interdisciplinary Nanoscience Center, Aarhus University. Electronic address: nina.iversen@biology.au.dk.
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