| Superparamagnetic iron oxide: detection of focal liver lesions at high-field-strength MR imaging. | |
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MedLine Citation:
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PMID: 8061426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AMI-25 was evaluated at 1.5 T as a superparamagnetic iron oxide contrast agent for the liver. Sixteen patients with up to five suspected focal liver lesions were examined with T1-, proton-density-, and T2-weighted spin-echo sequences before and after intravenous administration of AMI-25 (15 mumol/kg iron). The contrast-to-noise ratio (C/N) increased from 1.8 to 3.5 on 600/15 (TR msec/TE msec) images and from 1.7 to 7.9 on 2,500/15 images after AMI-25 administration (P < .01). C/N did not change significantly on 2,500/90 images. Two blinded readers counted the number of lesions visible on unenhanced and contrast-enhanced images, with the 32 sets of images of the 16 patients presented in random order. Both readers identified more lesions on AMI-25-enhanced images, but the difference was not statistically significant (P > .05). Two patients reported minor side effects (flushing, sensation of heat, lower back pain). On the basis of the results obtained in a limited number of patients, the authors conclude that at 1.5 T, AMI-25 does not significantly improve the detection of focal liver lesions on conventional spin-echo images. |
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Authors:
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S H Duda; M Laniado; A F Kopp; E Grönewäller; K P Aicher; P Pavone; E Jehle; C D Claussen |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 4 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 1994 May-Jun |
Date Detail:
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Created Date: 1994-09-20 Completed Date: 1994-09-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 309-14 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, Eberhard-Karls-Universität Tübingen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Contrast Media*
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adverse effects Female Ferrosoferric Oxide Galactans / administration & dosage, diagnostic use* Humans Image Processing, Computer-Assisted Iron / administration & dosage, adverse effects, diagnostic use* Liver / pathology* Liver Diseases / diagnosis* Liver Neoplasms / diagnosis*, secondary Magnetic Resonance Imaging / methods* Male Middle Aged Oxides / administration & dosage, adverse effects, diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/BMS 180550; 0/Contrast Media; 0/Galactans; 0/Oxides; 119683-68-0/ferumoxides; 1317-61-9/Ferrosoferric Oxide; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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