Document Detail


Superoxide production in neutrophils of patients with rheumatoid arthritis and Felty's syndrome.
MedLine Citation:
PMID:  6315935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The production of superoxide by N-formylmethionyl-leucyl-phenylalanine activated neutrophils was measured prospectively with a ferricytochrome C reduction assay in 33 normals, 33 patients with rheumatoid arthritis and 9 patients with Felty's syndrome. Both the rate and quantity of superoxide production were significantly lower in patients with Felty's syndrome when compared to the other 2 groups. This finding suggests a possible additional factor in the increased propensity of these patients to develop infections.
Authors:
P L Chiu; P Davis; K Wong; M Dasgupta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  10     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  694-700     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / metabolism*
Felty's Syndrome / metabolism*
Female
Humans
Male
Neutrophils / metabolism*
Prospective Studies
Superoxides / biosynthesis*
Chemical
Reg. No./Substance:
11062-77-4/Superoxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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