Document Detail


Superoxide production by polymorphonuclear leucocytes in rheumatoid arthritis and osteoarthritis: in vivo inhibition by the antirheumatic drug piroxicam due to interference with the activation of the NADPH-oxidase.
MedLine Citation:
PMID:  3006613     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The superoxide (O2-) production of stimulated polymorphonuclear leucocytes is increased in patients with rheumatoid arthritis and osteoarthritis compared with controls. Treatment of these different groups with pharmacological amounts of the non-steroidal anti-inflammatory drug piroxicam in vivo resulted in a decrease of about 25% in O2- secretion by isolated granulocytes. In vitro experiments showed that piroxicam inhibits O2- production of granulocytes by interference with the stimulation of the NADPH-oxidase. Piroxicam caused diminished O2- production of membrane fragments if it was present during the stimulation of the NADPH-oxidase of the intact cells. During the actual O2- production of the stimulated membrane fragments piroxicam had no effect. It is concluded that piroxicam is able to inhibit granulocyte O2- production by blocking the activation of NADPH-oxidase, which results in diminished tissue destruction by oxygen free radicals in inflammatory diseases.
Authors:
P Biemond; A J Swaak; J M Penders; C M Beindorff; J F Koster
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  45     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-24     Completed Date:  1986-04-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  249-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arthritis / blood*
Arthritis, Rheumatoid / blood
Humans
NADH, NADPH Oxidoreductases / blood*
NADPH Oxidase
Neutrophils / drug effects,  metabolism*
Osteoarthritis / blood
Piroxicam
Superoxides / antagonists & inhibitors,  metabolism*
Tetradecanoylphorbol Acetate / pharmacology
Thiazines / pharmacology*
Chemical
Reg. No./Substance:
0/Thiazines; 11062-77-4/Superoxides; 16561-29-8/Tetradecanoylphorbol Acetate; 36322-90-4/Piroxicam; EC 1.6.-/NADH, NADPH Oxidoreductases; EC 1.6.3.1/NADPH Oxidase
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