| Superoxide production by polymorphonuclear leucocytes in rheumatoid arthritis and osteoarthritis: in vivo inhibition by the antirheumatic drug piroxicam due to interference with the activation of the NADPH-oxidase. | |
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MedLine Citation:
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PMID: 3006613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The superoxide (O2-) production of stimulated polymorphonuclear leucocytes is increased in patients with rheumatoid arthritis and osteoarthritis compared with controls. Treatment of these different groups with pharmacological amounts of the non-steroidal anti-inflammatory drug piroxicam in vivo resulted in a decrease of about 25% in O2- secretion by isolated granulocytes. In vitro experiments showed that piroxicam inhibits O2- production of granulocytes by interference with the stimulation of the NADPH-oxidase. Piroxicam caused diminished O2- production of membrane fragments if it was present during the stimulation of the NADPH-oxidase of the intact cells. During the actual O2- production of the stimulated membrane fragments piroxicam had no effect. It is concluded that piroxicam is able to inhibit granulocyte O2- production by blocking the activation of NADPH-oxidase, which results in diminished tissue destruction by oxygen free radicals in inflammatory diseases. |
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Authors:
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P Biemond; A J Swaak; J M Penders; C M Beindorff; J F Koster |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 45 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-04-24 Completed Date: 1986-04-24 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 249-55 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis
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blood* Arthritis, Rheumatoid / blood Humans NADH, NADPH Oxidoreductases / blood* NADPH Oxidase Neutrophils / drug effects, metabolism* Osteoarthritis / blood Piroxicam Superoxides / antagonists & inhibitors, metabolism* Tetradecanoylphorbol Acetate / pharmacology Thiazines / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Thiazines; 11062-77-4/Superoxides; 16561-29-8/Tetradecanoylphorbol Acetate; 36322-90-4/Piroxicam; EC 1.6.-/NADH, NADPH Oxidoreductases; EC 1.6.3.1/NADPH Oxidase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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