| Superoxide dismutase reduces islet microvascular injury induced by streptozotocin in the rat. | |
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MedLine Citation:
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PMID: 9277392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenous administration of streptozotocin (STZ) leads to permanent diabetes mellitus in rats. We investigated the possible role of islet microcirculatory changes and free radical formation in this animal model. In vivo fluorescence microscopy was performed for 4 h after administration of STZ. Vascular permeability, capillary blood flow, and endothelial leukocyte adhesion were measured in endocrine and exocrine pancreatic tissue. The earliest microcirculatory event was an increase in vascular permeability in pancreatic islets, with a peak 1 h after STZ administration. The difference between islet and exocrine tissue light intensity was +15.8 +/- 5.6% at t = 60 min. Islet blood flow velocity significantly decreased after 3 h, whereas blood flow in the exocrine pancreas was not affected. Complete stasis of islet blood flow was observed only in rats receiving STZ. Neither increased leukocyte adhesion to islet vascular endothelium nor ischemia-reperfusion phenomena were observed. Prophylactic administration of the radical scavenger superoxide dismutase prevented STZ-induced damage to the islet microcirculation in the initial phase of this model. We conclude that STZ leads to severe microcirculatory disturbances within pancreatic islets in rats. Apparently, these changes are mediated at least in part by free oxygen radicals. |
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Authors:
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M Enghofer; K H Usadel; O Beck; K Kusterer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 273 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-24 Completed Date: 1997-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E376-82 Citation Subset: IM |
Affiliation:
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Department of Medicine I, Johann Wolfgang Goethe University, Frankfurt am Main, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis Blood Vessels / drug effects, pathology Capillaries / physiology Capillary Permeability / drug effects Celiac Artery / physiology, ultrasonography Cell Adhesion / drug effects Female Islets of Langerhans / blood supply* Leukocytes / physiology Microcirculation / drug effects Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects Streptozocin / pharmacology* Superoxide Dismutase / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 18883-66-4/Streptozocin; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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