Document Detail

Superoxide dismutase failed to attenuate allergen-induced nasal congestion in ragweed-sensitized dogs.
MedLine Citation:
PMID:  15608092     Owner:  NLM     Status:  MEDLINE    
We hypothesized that augmentation of antioxidant defenses with exogenous superoxide dismutase (SOD), an enzyme that provides an initial defense against oxidative injury, would attenuate allergen-induced nasal congestion in the canine model of allergic rhinitis. Nasal congestion was evaluated by the measurements of nasal resistance and the volume of the nasal passage. In five nonsensitized dogs, 30,000 U of SOD from bovine erythrocytes delivered by aerosol to the nasal passages before histamine challenge reduced the histamine-induced nasal congestion. At 30 min postchallenge, nasal resistance was 1.14 +/- 0.2 cmH2O.l(-1).min(-1) in the saline pretreatment study vs. 0.36 +/- 0.02 cmH2O.l(-1).min(-1) in the SOD pretreatment study (P < 0.05), and volume of nasal passage was 10.9 +/- 0.5 cm3 vs. 17.4 +/- 1.3 cm3 (P < 0.05), respectively. In five sensitized dogs, however, neither an analogous pretreatment with SOD nor intranasal aerosolized pretreatment with 30,000 U of SOD conjugated to polyethylene glycol attenuated ragweed-induced nasal congestion. Also, systemic application of SOD did not attenuate responses to challenges with histamine and ragweed in nonsensitized and sensitized dogs, respectively. The antioxidant-induced attenuation of nasal congestion in nonsensitized dogs confirms validity of the model and indicates the involvement of free radical-mediated damage in the genesis of the histamine-induced congestion. In sensitized dogs, the data do not support the hypothesis that oxidative stress is a clinically significant component of acute ragweed-induced nasal congestion. The data do not support the use of SOD for acute protection against allergic rhinitis.
Natalia Skorohod; Donovan B Yeates
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2004-12-17
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  98     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-17     Completed Date:  2005-07-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1478-86     Citation Subset:  IM    
Dept. of Medicine, M/C 788, Univ. of Illinois at Chicago, Chicago, IL 60612, USA.
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MeSH Terms
Administration, Inhalation
Allergens / adverse effects*
Ambrosia / adverse effects*
Histamine / diagnostic use
Injections, Intramuscular
Injections, Intravenous
Nasal Obstruction / diagnosis,  drug therapy*,  etiology*
Nasal Provocation Tests / methods
Pollen / adverse effects*
Rhinitis, Allergic, Seasonal / diagnosis,  drug therapy*,  etiology*
Severity of Illness Index
Superoxide Dismutase / administration & dosage*
Treatment Failure
Grant Support
Reg. No./Substance:
0/Allergens; 51-45-6/Histamine; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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