| Superoxide dismutase failed to attenuate allergen-induced nasal congestion in ragweed-sensitized dogs. | |
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MedLine Citation:
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PMID: 15608092 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We hypothesized that augmentation of antioxidant defenses with exogenous superoxide dismutase (SOD), an enzyme that provides an initial defense against oxidative injury, would attenuate allergen-induced nasal congestion in the canine model of allergic rhinitis. Nasal congestion was evaluated by the measurements of nasal resistance and the volume of the nasal passage. In five nonsensitized dogs, 30,000 U of SOD from bovine erythrocytes delivered by aerosol to the nasal passages before histamine challenge reduced the histamine-induced nasal congestion. At 30 min postchallenge, nasal resistance was 1.14 +/- 0.2 cmH2O.l(-1).min(-1) in the saline pretreatment study vs. 0.36 +/- 0.02 cmH2O.l(-1).min(-1) in the SOD pretreatment study (P < 0.05), and volume of nasal passage was 10.9 +/- 0.5 cm3 vs. 17.4 +/- 1.3 cm3 (P < 0.05), respectively. In five sensitized dogs, however, neither an analogous pretreatment with SOD nor intranasal aerosolized pretreatment with 30,000 U of SOD conjugated to polyethylene glycol attenuated ragweed-induced nasal congestion. Also, systemic application of SOD did not attenuate responses to challenges with histamine and ragweed in nonsensitized and sensitized dogs, respectively. The antioxidant-induced attenuation of nasal congestion in nonsensitized dogs confirms validity of the model and indicates the involvement of free radical-mediated damage in the genesis of the histamine-induced congestion. In sensitized dogs, the data do not support the hypothesis that oxidative stress is a clinically significant component of acute ragweed-induced nasal congestion. The data do not support the use of SOD for acute protection against allergic rhinitis. |
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Authors:
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Natalia Skorohod; Donovan B Yeates |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2004-12-17 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 98 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-17 Completed Date: 2005-07-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1478-86 Citation Subset: IM |
Affiliation:
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Dept. of Medicine, M/C 788, Univ. of Illinois at Chicago, Chicago, IL 60612, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Allergens / adverse effects* Ambrosia / adverse effects* Animals Dogs Histamine / diagnostic use Injections, Intramuscular Injections, Intravenous Nasal Obstruction / diagnosis, drug therapy*, etiology* Nasal Provocation Tests / methods Pollen / adverse effects* Rhinitis, Allergic, Seasonal / diagnosis, drug therapy*, etiology* Severity of Illness Index Superoxide Dismutase / administration & dosage* Treatment Failure |
| Grant Support | |
ID/Acronym/Agency:
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5RO1 ES08982-05/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 51-45-6/Histamine; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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