Document Detail

Superoxide dismutase derivative reduces oxidative damage in skeletal muscle of rats during exhaustive exercise.
MedLine Citation:
PMID:  7559209     Owner:  NLM     Status:  MEDLINE    
A superoxide dismutase derivative (SM-SOD) that circulates and is bound to albumin with a half-life of 6 h was injected intraperitoneally into rats before exhaustive treadmill running to study its antioxidant scavenging capacity in the plasma and soleus and tibialis muscles. The exercise induced a marked increase in xanthine oxidase activity in plasma and an increase in thiobarbituric acid-reactive substances in the plasma as well as in the soleus and tibialis muscles of nonadministered rats immediately after the exercise. The immunoreactive content and activity of both SOD isoenzymes (Cu,Zn-SOD and Mn-SOD) of the nonadministered rats increased in the soleus and tibialis muscles immediately after running. SM-SOD treatment definitely attenuated the degree of the increase in thiobarbituric acid-reactive substances and xanthine oxidase in all samples examined immediately after exercise. Glutathione peroxidase activity significantly increased in the soleus muscle of nonadministered rats 1 day after running, whereas catalase activity remained unchanged throughout the experimental period. These results suggest that a single bout of exhaustive exercise induces oxidative stress in skeletal muscle of rats and that this oxidative stress can be attenuated by exogenous SM-SOD.
Z Radák; K Asano; M Inoue; T Kizaki; S Oh-Ishi; K Suzuki; N Taniguchi; H Ohno
Related Documents :
22584959 - Effects of lightweight outdoor clothing on the prevention of hypothermia during low-int...
10364419 - Nutritional antioxidants as therapeutic and preventive modalities in exercise-induced m...
22377939 - Effect of hyperoxic-supplemented interval training on endurance performance in trained ...
22500229 - Effects of high-speed power training on muscle performance and braking speed in older a...
15256219 - Oxidative stress and delayed-onset muscle damage after exercise.
19089749 - The effects of a 4-week coffeeberry supplementation on antioxidant status, endurance, a...
6511559 - Time course of loss of adaptations after stopping prolonged intense endurance training.
16778069 - Role of brain il-1beta on fatigue after exercise-induced muscle damage.
15131559 - Effect of a cardiac rehabilitation program on left ventricular diastolic function and i...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  79     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-14     Completed Date:  1995-11-14     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-35     Citation Subset:  IM; S    
Laboratory of Exercise Physiology, University of Tsukuba, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Catalase / metabolism
Glutathione / metabolism
Lipid Peroxides / metabolism
Muscle, Skeletal / drug effects*,  metabolism*,  pathology
Oxidative Stress*
Physical Endurance*
Physical Exertion*
Polystyrenes / metabolism,  pharmacology*
Rats, Wistar
Superoxide Dismutase / metabolism,  pharmacology*
Xanthine Oxidase / blood
Reg. No./Substance:
0/Lipid Peroxides; 0/Polystyrenes; 0/superoxide dismutase-poly(styrene co-maleic acid butyl ester); 70-18-8/Glutathione; EC; EC Dismutase; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lipocortin-1 distribution in bronchoalveolar lavage from healthy human lung: effect of prednisolone.
Next Document:  Brain glucose metabolism in hypobaric hypoxia.