Document Detail

Superoxide dismutase derivative reduces oxidative damage in skeletal muscle of rats during exhaustive exercise.
MedLine Citation:
PMID:  7559209     Owner:  NLM     Status:  MEDLINE    
A superoxide dismutase derivative (SM-SOD) that circulates and is bound to albumin with a half-life of 6 h was injected intraperitoneally into rats before exhaustive treadmill running to study its antioxidant scavenging capacity in the plasma and soleus and tibialis muscles. The exercise induced a marked increase in xanthine oxidase activity in plasma and an increase in thiobarbituric acid-reactive substances in the plasma as well as in the soleus and tibialis muscles of nonadministered rats immediately after the exercise. The immunoreactive content and activity of both SOD isoenzymes (Cu,Zn-SOD and Mn-SOD) of the nonadministered rats increased in the soleus and tibialis muscles immediately after running. SM-SOD treatment definitely attenuated the degree of the increase in thiobarbituric acid-reactive substances and xanthine oxidase in all samples examined immediately after exercise. Glutathione peroxidase activity significantly increased in the soleus muscle of nonadministered rats 1 day after running, whereas catalase activity remained unchanged throughout the experimental period. These results suggest that a single bout of exhaustive exercise induces oxidative stress in skeletal muscle of rats and that this oxidative stress can be attenuated by exogenous SM-SOD.
Z Radák; K Asano; M Inoue; T Kizaki; S Oh-Ishi; K Suzuki; N Taniguchi; H Ohno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  79     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-14     Completed Date:  1995-11-14     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-35     Citation Subset:  IM; S    
Laboratory of Exercise Physiology, University of Tsukuba, Japan.
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MeSH Terms
Catalase / metabolism
Glutathione / metabolism
Lipid Peroxides / metabolism
Muscle, Skeletal / drug effects*,  metabolism*,  pathology
Oxidative Stress*
Physical Endurance*
Physical Exertion*
Polystyrenes / metabolism,  pharmacology*
Rats, Wistar
Superoxide Dismutase / metabolism,  pharmacology*
Xanthine Oxidase / blood
Reg. No./Substance:
0/Lipid Peroxides; 0/Polystyrenes; 0/superoxide dismutase-poly(styrene co-maleic acid butyl ester); 70-18-8/Glutathione; EC; EC Dismutase; EC Oxidase

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