| Superoxide dismutase decreases reperfusion arrhythmias and preserves myocardial function during thrombolysis with tissue plasminogen activator. | |
| | |
MedLine Citation:
|
PMID: 1696653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Release of superoxide radicals during the early phase of coronary reperfusion may result in degradation of endothelium-derived relaxing factor (EDRF), extension of myocardial injury, precipitation of arrhythmias, and stimulation of platelet aggregation. These factors may relate to the occurrence of ventricular fibrillation during reperfusion and coronary reocclusion following initial thrombolysis. This study was designed to examine the effects of concomitant administration of superoxide radical scavenger superoxide dismutase (SOD) with tissue plasminogen activator (tPA) compared to tPA alone (without SOD) in acute coronary thrombosis in anesthetized dogs. Dogs with a stable electrically induced coronary thrombus were randomly given intravenously tPA (0.75 mg/kg) alone or SOD bolus (2 mg/kg) followed by SOD (4 mg/kg) + tPA (0.75 mg/kg) over 20 min. tPA alone restored coronary blood flow in six of nine dogs (reperfusion rate of 67%) with time to reflow of 18.5 +/- 6.7 (mean +/- SD) min. Coronary reocclusion occurred spontaneously in four of six dogs with initial reperfusion (reocclusion rate of 67%). In contrast, SOD + tPA restored coronary blood flow in 9 of 12 dogs (reperfusion rate of 75%, not significant vs. tPA alone) with time to reflow of 11.3 +/- 4.8 min and coronary reocclusion occurred in only 3 of 9 dogs with reperfusion (reocclusion rate of 33%, not significant vs. tPA alone). Reperfusion arrhythmias were more frequent in dogs who received tPA alone compared to those who received SOD in addition to tPA (mean Holter-monitored PVC count of 730 vs. 12 beats/h, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
J L Mehta; W W Nichols; T G Saldeen; V K Chandna; F A Nicolini; D L Lawson; M F ter Riet |
Related Documents
:
|
3335053 - Effects of calcium channel blocker on responses of blood flow, function, arrhythmias, a... 10807653 - Caspase inhibition and limitation of myocardial infarct size: protection against lethal... 2112623 - Incidence of arrhythmia with central venous catheter insertion and exchange. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 16 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1990 Jul |
Date Detail:
|
Created Date: 1990-09-18 Completed Date: 1990-09-18 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 112-20 Citation Subset: IM |
Affiliation:
|
Department of Medicine, University of Florida College of Medicine, Gainesville. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
pharmacology Animals Arrhythmias, Cardiac / etiology, physiopathology, prevention & control* Coronary Disease / drug therapy* Coronary Thrombosis / complications, drug therapy*, physiopathology Coronary Vessels / drug effects Dogs Female Heart / drug effects* Hemodynamics / drug effects Myocardial Reperfusion Platelet Aggregation / drug effects Recombinant Proteins / therapeutic use Superoxide Dismutase / therapeutic use* Thrombolytic Therapy* Tissue Plasminogen Activator / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Recombinant Proteins; 51-84-3/Acetylcholine; EC 1.15.1.1/Superoxide Dismutase; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pharmacokinetics of recombinant human superoxide dismutase.
Next Document: Ceranapril (SQ 29,852), an orally active inhibitor of angiotensin converting enzyme (ACE).