| Superoxide dismutase (SOD) as a potential inhibitory mediator of inflammation via neutrophil apoptosis. | |
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MedLine Citation:
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PMID: 16036355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Superoxide dismutase (SOD) is supposed to be an effective agent for neutrophil-mediated inflammation in the area of critical medicine. We investigated the involvement of SOD in the regulation of neutrophil apoptosis. Exogenously added SOD effectively induced neutrophil apoptosis, and the fluorescence patterns determined using annexin-V and the 7-AAD were similar to those seen in Fas-mediated neutrophil apoptosis. Neutrophils are short-lived leukocytes that need to be removed safely by apoptosis. The clearance of apoptotic neutrophils from sites of inflammation is a crucial determinant of the resolution of inflammation. Catalase inhibited the neutrophil apoptosis and caspase-3 activation. Spontaneous apoptosis, hydrogen peroxide and anti-Fas antibody-induced apoptosis of neutrophils were accelerated in Down's syndrome patients, in whom the SOD gene is overexpressed. Hydrogen peroxide was thought to be a possible major mediator of ROS-induced neutrophil apoptosis in caspase-dependent manner. Neutrophil apoptosis represents a crucial step in the mechanism governing the resolution of inflammation and has been suggested as a possible target for the control of neutrophil-mediated tissue injury. SOD may be a potential inhibitory mediator of neutrophil-mediated inflammation. |
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Authors:
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Kozo Yasui; Norimoto Kobayashi; Takashi Yamazaki; Kazunaga Agematsu; Satoshi Matsuzaki; Susumu Ito; Setsuko Nakata; Atsushi Baba; Kenichi Koike |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Free radical research Volume: 39 ISSN: 1071-5762 ISO Abbreviation: Free Radic. Res. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-22 Completed Date: 2005-10-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423872 Medline TA: Free Radic Res Country: England |
Other Details:
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Languages: eng Pagination: 755-62 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan. k-yasui@hsp.md.shinshu-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Annexin A5 / analysis Antibodies, Monoclonal / pharmacology Apoptosis / drug effects*, immunology Caspase 3 Caspases / metabolism Down Syndrome / blood, enzymology Enzyme Activation Flow Cytometry Humans Inflammation / blood Neutrophils / cytology*, drug effects*, enzymology, immunology Reactive Oxygen Species / metabolism Superoxide Dismutase / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Annexin A5; 0/Antibodies, Monoclonal; 0/Reactive Oxygen Species; 0/anti-Fas monoclonal antibody; EC 1.15.1.1/Superoxide Dismutase; EC 3.4.22.-/CASP3 protein, human; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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