| Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases. | |
| | |
MedLine Citation:
|
PMID: 22119635 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The association between the superoxide dismutase 2 (SOD2) Val16Ala polymorphism and the serum aminotransferase levels was retrospectively investigated in 207 valproic acid-treated patients with epilepsy. The Val/Val genotype tended to show elevated alanine aminotransferase levels (odds ratio=3.5; P=0.056). In addition, an elevated γ-glutamyltransferase level was associated with the Val/Val genotype (odds ratio=3.1; P=0.022). The SOD2 Val/Val genotype may therefore contribute to a valproic acid-induced elevation in the serum aminotransferase levels. |
| | |
Authors:
|
Junji Saruwatari; Mariko Deguchi; Yuki Yoshimori; Madoka Noai; Shiho Yoshida; Naoki Ogusu; Kentaro Oniki; Shuichi Yoshida; Norio Yasui-Furukori; Sunao Kaneko; Takateru Ishitsu; Kazuko Nakagawa |
Related Documents
:
|
171245 - Studies in lipid histochemistry. xiii. the opa (osmiumtetroxide-periodic acid-alpha-nap... 6111555 - Effect of cerulenin on cellular autolytic activity and lipid metabolism during inhibiti... 6888425 - The occurrence of proteolipid antigens in schistosoma mansoni. 18040975 - Phenotypic flexibility in cutaneous water loss and lipids of the stratum corneum in hou... 2757385 - Excretion of amino acids by 1,2,4-triazole-3-alanine-resistant mutants of methanococcus... 1124355 - The combined effect of pentagastrin and magnesium on gastric acid secretion in man. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-23 |
Journal Detail:
|
Title: Epilepsy research Volume: - ISSN: 1872-6844 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
|
Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Study of equivalence: spinal bupivacaine 15mg versus bupivacaine 12mg with fentanyl 15?g for cesarea...
Next Document: Low glycemic index treatment for epilepsy in tuberous sclerosis complex.