| Superoxide anions mediate proliferative response in cardiac fibroblasts. | |
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MedLine Citation:
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PMID: 10935319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The study was undertaken to examine whether superoxide anions mediate a proliferative response in cardiac fibroblasts. Cardiac fibroblasts isolated from newborn Wistar rats were exposed to superoxide anion generating system (hypoxanthine + xanthine oxidase) and its effect on cell growth was assessed. A stimulatory response on fibroblast proliferation was observed. The proportion of proliferating cells increased within 3 h of treatment compared to the control and the cell density after 96 h of exposure remained significantly high (P < 0.0005). Inclusion of antioxidants neutralised the stimulatory response, fortifying the role of superoxide anions in cell proliferation. This observation indicates that superoxide anions can mediate a fibrotic reaction in the cardiac tissue. |
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Authors:
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R Preeta; R R Nair |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Indian journal of medical research Volume: 111 ISSN: 0971-5916 ISO Abbreviation: Indian J. Med. Res. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-08-17 Completed Date: 2000-08-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374701 Medline TA: Indian J Med Res Country: INDIA |
Other Details:
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Languages: eng Pagination: 127-32 Citation Subset: IM |
Affiliation:
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Division of Cellular & Molecular Cardiology, Sree Chitra Thirunal Institute for Medical Sciences & Technology, Thiruvananthapuram. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division Cells, Cultured Fibroblasts / physiology Myocardium / cytology* Proliferating Cell Nuclear Antigen / analysis Rats Rats, Wistar Superoxides / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Proliferating Cell Nuclear Antigen; 11062-77-4/Superoxides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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