| Superoxide anion: oncogenic reactive oxygen species? | |
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MedLine Citation:
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PMID: 17531522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent evidence linking intracellular reactive oxygen species to cell survival and/or proliferation signals has resulted in a paradigm shift from the age-old dogma implicating reactive oxygen species exclusively in cell damage and death. It is now accepted that reactive oxygen species play important roles in normal physiological states and that depending on the species involved the effect could be highly varied. In this regard, the effects of the two major reactive oxygen species, superoxide and hydrogen peroxide have been extensively studied. During normal cell growth a tight balance between the two species is kept under check by the cells' anti-oxidant defense systems. Deficiency or defect in this defense armory is invariably associated with neoplasia, thus rendering the intracellular redox status in a state of imbalance and generating a "pro-oxidant" milieu. A variety of model systems have underscored the relationship between a pro-oxidant state and cancer promotion and progression. In this review, we present evidence to support the hypothesis that the effect of intracellular reactive oxygen species on oncogenesis is dependent on the ratio of intracellular superoxide to hydrogen peroxide in that a predominant increase in superoxide supports cell survival and promotes oncogenesis whereas a tilt in favor of hydrogen peroxide prevents carcinogenesis by facilitating cell death signaling. |
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Authors:
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Shazib Pervaiz; Marie-Veronique Clement |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-04-21 |
Journal Detail:
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Title: The international journal of biochemistry & cell biology Volume: 39 ISSN: 1357-2725 ISO Abbreviation: Int. J. Biochem. Cell Biol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-07-13 Completed Date: 2007-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508482 Medline TA: Int J Biochem Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 1297-304 Citation Subset: IM |
Affiliation:
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Cancer Biology Program, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. phssp@nus.edu.sg |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Transformation, Neoplastic / metabolism* Humans Hydrogen Peroxide / metabolism* Neoplasms / metabolism* Reactive Oxygen Species / metabolism* Signal Transduction Superoxides / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; 11062-77-4/Superoxides; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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