Document Detail

Superovulation-induced intrauterine growth retardation in mice.
MedLine Citation:
PMID:  7282827     Owner:  NLM     Status:  MEDLINE    
Existing animal models for inducing intrauterine growth retardation (IUGR) involve severe maternal compromise or acute fetal insult. We postulated that superovulation would produce IUGR gradually by enhancing fetal competition for nutrients. Mice were superovulated with pregnant mare serum and human chorionic gonadotrophin and killed on day 19 of gestation. Compared to controls, the mean number of fetuses was significantly increased; body, brain, liver, and placental weights were reduced; and brain/liver weight ratios were increased. Additional mice underwent partial unilateral oophorectomy before superovulation. Marked asymmetry in the number of fetuses in the two uterine horns of the same mother was produced, and the fetuses on the more crowded side manifested smaller brains and livers an increased brain/liver ratios. In the mouse, superovulation is a simple, preconceptual method for achieving IUGR and may be combined with partial unilateral oophorectomy to permit comparisons between fetuses with different growth characteristics within the same mother.
M I Evans; J D Schulman; L Golden; A B Mukherjee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  141     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1981-11-22     Completed Date:  1981-11-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  433-5     Citation Subset:  AIM; IM    
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MeSH Terms
Brain / anatomy & histology
Chorionic Gonadotropin / pharmacology
Fetal Growth Retardation / etiology*
Gonadotropins, Equine / pharmacology
Liver / anatomy & histology
Organ Size
Ovulation* / drug effects
Placenta / anatomy & histology
Superovulation* / drug effects
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Gonadotropins, Equine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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