| Superiority of oral verapamil therapy to digoxin in treatment of chronic atrial fibrillation. | |
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MedLine Citation:
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PMID: 6337787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy and safety of oral verapamil, 240 mg, with or without digoxin were studied in 52 patients with chronic atrial fibrillation at rest, and during mild and maximal exercise. Twenty-four patients were studied during the following therapeutic modalities: no therapy; digoxin, 0.25 mg and 0.5 mg daily; digoxin, 0.25 mg and verapamil; and verapamil alone. Heart rate at rest and during all levels of exercise was decreased significantly (p less than 0.005), either by combining digoxin with verapamil or by verapamil therapy alone. In contrast, the excessive heart rate response to exercise was not prevented by digoxin even with good serum concentrations. The improved control of heart rate with verapamil was associated with a significantly improved exercise capacity. Verapamil is an important and safe modality of treatment, with or without digoxin, in the long-term control of heart rate in chronic atrial fibrillation. It is superior to digoxin in controlling the ventricular rate and in improving exercise capacity. |
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Authors:
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R Lang; H O Klein; E Weiss; D David; P Sareli; A Levy; J Guerrero; E Di Segni; E Kaplinsky |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Chest Volume: 83 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1983 Mar |
Date Detail:
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Created Date: 1983-04-07 Completed Date: 1983-04-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 491-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Atrial Fibrillation / drug therapy*, physiopathology Clinical Trials as Topic Digoxin / administration & dosage, metabolism, therapeutic use* Drug Therapy, Combination Exercise Test Female Half-Life Heart Rate / drug effects Humans Male Middle Aged Time Factors Verapamil / administration & dosage, metabolism, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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20830-75-5/Digoxin; 52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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