| Superior colliculus inactivation alters the weighted integration of visual stimuli. | |
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MedLine Citation:
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PMID: 21632927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The primate superior colliculus (SC) is important for the winner-take-all selection of targets for orienting movements. Such selection takes time, however, and the earliest motor responses typically are guided by a weighted vector average of the visual stimuli, before the winner-take-all selection of a single target. We tested whether SC activity plays a role in this initial stage of orienting by inactivating the SC in two macaques (Macaca mulatta) with local muscimol injections. After SC inactivation, initial orienting responses still followed a vector average, but the contribution of the visual stimulus inside the affected field was decreased, and the contribution of the stimulus outside the affected field was increased. These results demonstrate that the SC plays an important role in the weighted integration of visual signals for orienting, in addition to its role in the winner-take-all selection of the target. |
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Authors:
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Samuel U Nummela; Richard J Krauzlis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-02 Completed Date: 2011-08-23 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 8059-66 Citation Subset: IM |
Affiliation:
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Systems Neurobiology Laboratory, Salk Institute for Biological Studies, University of California, San Diego, La Jolla, California 92037, USA. snummela@salk.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Eye Movements / physiology Macaca mulatta Male Microinjections / methods Muscimol / administration & dosage, pharmacology Orientation / physiology Photic Stimulation / methods* Psychomotor Performance / physiology Reaction Time / drug effects, physiology Superior Colliculi / drug effects, physiology* Visual Perception / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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EY012212/EY/NEI NIH HHS; R01 EY012212-13/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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2763-96-4/Muscimol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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