Document Detail


Superior T memory stem cell persistence supports long-lived T cell memory.
MedLine Citation:
PMID:  23281401     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-lived memory T cells are able to persist in the host in the absence of antigen; however, the mechanism by which they are maintained is not well understood. Recently, a subset of human T cells, stem cell memory T cells (TSCM cells), was shown to be self-renewing and multipotent, thereby providing a potential reservoir for T cell memory throughout life. However, their in vivo dynamics and homeostasis still remain to be defined due to the lack of suitable animal models. We identified T cells with a TSCM phenotype and stem cell-like properties in nonhuman primates. These cells were the least-differentiated memory subset, were functionally distinct from conventional memory cells, and served as precursors of central memory. Antigen-specific TSCM cells preferentially localized to LNs and were virtually absent from mucosal surfaces. They were generated in the acute phase of viral infection, preferentially survived in comparison with all other memory cells following elimination of antigen, and stably persisted for the long term. Thus, one mechanism for maintenance of long-term T cell memory derives from the unique homeostatic properties of TSCM cells. Vaccination strategies designed to elicit durable cellular immunity should target the generation of TSCM cells.
Authors:
Enrico Lugli; Maria H Dominguez; Luca Gattinoni; Pratip K Chattopadhyay; Diane L Bolton; Kaimei Song; Nichole R Klatt; Jason M Brenchley; Monica Vaccari; Emma Gostick; David A Price; Thomas A Waldmann; Nicholas P Restifo; Genoveffa Franchini; Mario Roederer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2013-01-02
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-04-19     Completed Date:  2013-05-13     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  594-9     Citation Subset:  AIM; IM    
Affiliation:
ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, 40, Convent Dr., Bethesda, Maryland 20892, USA. luglie@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Viral
Cytokines / biosynthesis
Humans
Immunologic Memory*
Immunophenotyping
Lymphocyte Activation
Macaca mulatta / immunology
Macaca nemestrina / immunology
Multipotent Stem Cells / immunology*
Simian immunodeficiency virus / immunology
Species Specificity
T-Lymphocyte Subsets / immunology*
Grant Support
ID/Acronym/Agency:
Z99 AI999999/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Viral; 0/Cytokines
Comments/Corrections

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