Document Detail


Superheated water chromatography--a green technology for the future.
MedLine Citation:
PMID:  17658536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reversed phase liquid chromatography using superheated water as the mobile phase, at temperatures between 100 and 250 degrees C, offers a number of advantages for the analyst. It is an environmentally clean solvent, reducing solvent usage and disposal costs. It has advantages in detection, allowing UV spectra to be monitored down to short wavelengths, as well as a compatibility with universal flame ionisation detection and mass spectroscopy. By employing deuterium oxide as the eluent, solvent free NMR spectra can be measured. The development of newer more thermally stable stationary phases, including hybrid phases, have expanded the analytes that can be examined and these now range from alkylbenzenes, phenols, alkyl aryl ketones and a number of pharmaceuticals to carboxylic acids, amino acids, and carbohydrates. Very few compounds have been found to be unstable during the analysis. The separation methods can be directly coupled to superheated water extraction providing a totally solvent free system for sample extraction and analysis.
Authors:
Roger M Smith
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-07-05
Journal Detail:
Title:  Journal of chromatography. A     Volume:  1184     ISSN:  0021-9673     ISO Abbreviation:  J Chromatogr A     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-05-05     Revised Date:  2009-01-15    
Medline Journal Info:
Nlm Unique ID:  9318488     Medline TA:  J Chromatogr A     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  441-55     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Loughborough University, Loughborough, Leics LE11 3TU, UK. r.m.smith@lboro.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Benzene Derivatives / isolation & purification
Chromatography, Liquid / instrumentation,  methods*
Graphite / chemistry
Hot Temperature
Magnetic Resonance Spectroscopy
Mass Spectrometry
Silicon Dioxide / chemistry
Spectrophotometry
Zirconium
Chemical
Reg. No./Substance:
0/Benzene Derivatives; 1314-23-4/zirconium oxide; 7440-67-7/Zirconium; 7631-86-9/Silicon Dioxide; 7782-42-5/Graphite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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