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Superficial-spreading and nodular melanomas in Norway: a comparison by body site distribution and latitude gradients.
MedLine Citation:
PMID:  23010822     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Superficial-spreading melanoma (SSM) and nodular melanoma (NM) are the most common histological types of melanoma. These are seemingly distinct entities, on the basis of epidemiology, clinical behavior, tumor biological, and histological aspects as well as molecular characteristics. Intermittent sun exposure seems to play a major role in SSM, which has an increasing incidence rate during the last decades. However, relationship with sun exposure is more complex in the case of NM, as the latter may arise on any body part and has a more stable incidence rate. To obtain more information on the role of sun exposure in these two types of melanoma, we have compared body site distributions and latitude gradients for a period of 30 years in Norway. The study was based on official reports from the Cancer Registry of Norway, using melanoma incidence rates for a period of 30 years (1978-2007), by age, sex, anatomic site, and region of Norway. Our results show that in Norway, SSM is more strongly related to intermittent sun exposure than NM, as it arises mostly on the trunk as compared with the head and neck. Moreover, SSM has a higher incidence in the Southern regions of Norway, whereas for NM, the north-south gradient is not statistically significant. Differences in sun exposure at northern latitudes have a major impact on different types of melanoma. It seems that NM is less sun-induced than SSM, for which other etiological and pathogenetic factors may play important roles.
Authors:
Emanuela Micu; Zivile Baturaite; Asta Juzeniene; Oyvind S Bruland; Johan E Moan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-22
Journal Detail:
Title:  Melanoma research     Volume:  -     ISSN:  1473-5636     ISO Abbreviation:  Melanoma Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109623     Medline TA:  Melanoma Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartment of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital bFaculty of Medicine, University of Oslo cDepartment of Oncology, The Norwegian Radium Hospital dDepartment of Physics, University of Oslo, Oslo, Norway.
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