Document Detail


Superficial pseudoaneurysms: clinicopathologic aspects and involvement of extracellular matrix proteoglycans.
MedLine Citation:
PMID:  14976536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of proteoglycans in 21 temporal and two ulnar artery pseudoaneurysms was studied immunohistochemically. A history of trauma was elicited in six cases, and 16 of the lesions were pulsatile. The clinical diagnosis was aneurysm or cyst in 18 patients, possible arteritis in two patients, tumor in one patient, and unknown in the remaining patient. Histologically, there was a prominent myxoid neointimal response in the walls of each interrupted artery. The remnant arterial segment was often inconspicuous. Prominent smooth muscle cell proliferation and granulation tissue response with inflammation led to misdiagnosis of tumor or vasculitis, respectively, in 11 cases. Immunohistochemical staining for proteoglycans demonstrated abundant, diffuse versican in interrupted wall segments. Biglycan was confined to collagenized and vascularized areas. In some portions of medial disruption, in which angiogenesis was prominent, decorin was expressed within endothelial cells of neocapillaries. These findings demonstrate that superficial pseudoaneurysms may be mistaken clinically and pathologically for unrelated entities. The immunohistochemical studies confirm that versican is upregulated in areas of tensile stress. In addition, the presence of endothelial expression of decorin supports the concept of decorin's involvement in angiogenesis.
Authors:
Allen P Burke; Hannu Jarvelainen; Frank D Kolodgie; Ashita Goel; Thomas N Wight; Renu Virmani
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  17     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-19     Completed Date:  2004-10-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  482-8     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aneurysm, False / etiology,  metabolism,  pathology*
Biological Markers / analysis
Child
Extracellular Matrix / chemistry,  metabolism*
Extracellular Matrix Proteins
Female
Humans
Immunoenzyme Techniques
Lectins, C-Type
Male
Middle Aged
Proteochondroitin Sulfates / analysis,  metabolism
Proteoglycans / analysis,  metabolism*
Temporal Arteries / metabolism,  pathology*
Ulnar Artery / metabolism,  pathology
Versicans
Grant Support
ID/Acronym/Agency:
HL 18645-23/HL/NHLBI NIH HHS; R01 HL 61799-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Extracellular Matrix Proteins; 0/Lectins, C-Type; 0/Proteochondroitin Sulfates; 0/Proteoglycans; 0/VCAN protein, human; 0/decorin; 123939-84-4/biglycan; 126968-45-4/Versicans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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