| Superficial nephron responses to peritubular capillary infusions of angiotensins I and II. | |
| | |
MedLine Citation:
|
PMID: 3034074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Proximal tubular reabsorption, stop-flow pressure (SFP), and single nephron glomerular filtration rate (SNGFR) were measured in the absence of and during infusion of an isotonic saline solution containing either angiotensin I (ANG I; 10(-6) to 10(-5) M) or angiotensin II (ANG II; 10(-9) to 10(-7) M) into an adjacent peritubular capillary at a rate of 20 nl/min. Dilution of the infused ANG I and ANG II occurred in the peritubular capillary blood and as the peptides diffused into the interstitium. Infusion of either 10(-7) M ANG II or 10(-5) M ANG I increased proximal fractional fluid reabsorption (FRH2O) and decreased both SFP and SNGFR. There were no significant changes in FRH2O or SNGFR during infusion of 10(-5) M ANG I when the converting enzyme inhibitor enalaprilat (MK 422, 10(-3) M) was added to the infusate. Similarly, peritubular infusion at lower concentrations of either ANG II (10(-9) or 10(-8) M) or ANG I (10(-6) M) did not alter FRH2O, SFP, or SNGFR. These data indicate that conversion of ANG I to ANG II can occur in the peritubular capillary or interstitial environment and that increases above the normal endogenous levels in the postglomerular interstitial ANG II concentration can enhance proximal tubular reabsorption and increase preglomerular resistance and thereby reduce SNGFR. |
| | |
Authors:
|
K D Mitchell; L G Navar |
Related Documents
:
|
16618834 - Effect of low-density lipoprotein cholesterol on angiotensin ii sensitivity: a randomiz... 8230084 - Raa system and cardiovascular control in normal subjects, hypertensives and patients wi... 15106784 - Pathogenesis of structural vascular changes in hypertension. 22448394 - Testing for altruism and social pressure in charitable giving. 19892304 - Ambulatory blood pressure monitoring in stroke survivors: do we really control our pati... 23371394 - Renal hypertension: an unusual cause for a common problem. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 252 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1987 May |
Date Detail:
|
Created Date: 1987-06-17 Completed Date: 1987-06-17 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: F818-24 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin I
/
administration & dosage*,
antagonists & inhibitors,
pharmacology Angiotensin II / administration & dosage*, pharmacology Animals Capillaries Enalapril / analogs & derivatives, pharmacology Enalaprilat Glomerular Filtration Rate / drug effects Injections Kidney Tubules / blood supply, physiology* Male Nephrons / drug effects* Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
|
HL-18426/HL/NHLBI NIH HHS; HL-25451/HL/NHLBI NIH HHS; HL-26371/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
11128-99-7/Angiotensin II; 75847-73-3/Enalapril; 84680-54-6/Enalaprilat; 9041-90-1/Angiotensin I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Renal tubular secretion of the alkanesulfonate 2,3-dimercapto-1-propanesulfonate.
Next Document: Na+-K+-ATPase activity in medullary thick ascending limb during short-term anoxia.