Document Detail


Superficial and juxtamedullary nephron function during saline loading in the dog.
MedLine Citation:
PMID:  4815088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A modification of the microdissection technique of Hanssen was utilized in dogs to measure superficial (SNGFR) and juxtamedullary nephron filtration rate (JMGFR) in control and saline-expanded dogs. During control studies SNGFR was 60+/-4 and JMGFR was 72+/-5 nl/min. During saline loading SNGFR was 74+/-8 and JMGFR was 65+/-6 nl/min. The ratio SNGFR: JMGFR significantly increased from 0.84+/-0.03 to 1.15+/-0.08. Glomerular perfusion rate (GPR) was measured with the microsphere method during control and saline loading. Superficial GPR did not change significantly but juxtamedullary GPR increased from 225+/-42 to 323+/-39 nl/min. Calculated superficial nephron filtration fraction was unchanged after saline expansion but juxtamedullary filtration fraction decreased from 0.34+/-0.07 to 0.24+/-0.07. The data demonstrate a tendency for filtration to shift toward the superficial part and plasma flow toward the deep part of the kidney cortex. GFR in juxtamedullary nephrons appears to be less plasma flow-dependent than in superficial nephrons. The fall in filtration fraction in the deep cortex may affect sodium excretion by juxtamedullary nephrons.
Authors:
F J Bruns; E A Alexander; A L Riley; N G Levinsky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  53     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1974 Apr 
Date Detail:
Created Date:  1974-04-29     Completed Date:  1974-04-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  971-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity
Carbon Radioisotopes
Cesium Isotopes
Dogs
Ferrocyanides / diagnostic use
Filtration
Glomerular Filtration Rate*
Kidney / physiology*
Kidney Cortex / blood supply
Microspheres
Nephrons / drug effects,  physiology
Radioisotopes
Sodium Chloride / pharmacology*
Strontium Radioisotopes
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Cesium Isotopes; 0/Ferrocyanides; 0/Radioisotopes; 0/Strontium Radioisotopes; 7647-14-5/Sodium Chloride
Comments/Corrections

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