Document Detail


Superficial contact cryoablation attenuates experimentally created lung air leakage.
MedLine Citation:
PMID:  16202403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previously, we, and others found that cryoablation on normal lung produced localized pulmonary hemorrhage and edema, causing obliteration of air space. Therefore, we hypothesized that lung air leakage may be diminished by this procedure. In the present study, we examined if cryoablation can attenuate experimentally created lung air leakage. Male domestic pigs (n=4) underwent a thoracotomy. The lung was resected approximately 5 mm in diameter and 1mm in depth to create air leakage lesions. An argon gas cryoprobe with a copper plate attached to its tip was used to cryoablate the lesions superficially. After cryoablation, the positive airway pressure that produced macroscopic bubbles from each lesion site was compared between cryoablated and untreated lesions. Also, cryoablation of the lung surface was carried out in male Donryu rats (n=20) which were sequentially sacrificed to observe the histological changes over a time course. In the pigs, the air leakage pressure was significantly increased with cryoablation (40 cmH2O <) compared to no treatment (19+/-5 cmH2O) (p=0.021, Mann-Whitney U test). Histologically, cryoablation produced acute pulmonary hemorrhage and edema. In the rats, the region with extensive hemorrhage progressed to fibrosis in 1 month, and the areas with edema recovered. This study provides supportive evidence that cryoablation has the potential to stop air leakage from surface pulmonary injury. This procedure may provide a useful adjunct to surgical resection for spontaneous pneumothorax, and the control of air leakage from dissected raw lung surfaces during lung resection.
Authors:
Yotaro Izumi; Norimasa Tsukada; Eiji Ikeda; Masafumi Kawamura; Koichi Kobayashi
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Publication Detail:
Type:  Journal Article     Date:  2005-10-03
Journal Detail:
Title:  Cryobiology     Volume:  51     ISSN:  0011-2240     ISO Abbreviation:  Cryobiology     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006252     Medline TA:  Cryobiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  306-10     Citation Subset:  IM    
Affiliation:
Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cryosurgery / methods*
Disease Models, Animal
Hemorrhage / etiology,  pathology
Male
Pneumothorax / pathology,  surgery*
Pulmonary Edema / etiology,  pathology
Rats
Sus scrofa

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