| Superficial femoral artery plaque, the ankle-brachial index, and leg symptoms in peripheral arterial disease: the walking and leg circulation study (WALCS) III. | |
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MedLine Citation:
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PMID: 21436300 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The clinical significance of magnetic resonance-imaged plaque characteristics in the superficial femoral artery (SFA) is not well established. We studied associations of the ankle-brachial index (ABI) and leg symptoms with MRI-measured plaque area and percent lumen area in the SFA in participants with and without lower-extremity peripheral arterial disease (PAD). METHODS AND RESULTS: Four hundred twenty-seven participants (393 with PAD) underwent plaque imaging of the first 30 mm of the SFA. Twelve 2.5-mm cross-sectional images of the SFA were obtained. Outcomes were normalized plaque area, adjusted for artery size (0 to 1 scale, 1=greatest plaque), and lumen area, expressed as a percent of the total artery area. Adjusting for age, sex, race, smoking, statins, cholesterol, and other covariates, lower ABI values were associated with higher normalized mean plaque area (ABI <0.50:0.79; ABI 0.50 to 0.69:0.73; ABI 0.70 to 0.89:0.65; ABI 0.90 to 0.99:0.62; ABI 1.00 to 1.09:0.48; ABI 1.10 to 1.30:0.47 (P trend <0.001)) and smaller mean percent lumen area (P trend <0.001). Compared with PAD participants with intermittent claudication, asymptomatic PAD participants had lower normalized mean plaque area (0.72 versus 0.65, P=0.005) and larger mean percent lumen area (0.30 versus 0.36, P=0.01), adjusting for the ABI and other confounders. CONCLUSIONS: Lower ABI values are associated with greater MRI-measured plaque burden and smaller lumen area in the first 30 mm of the SFA. Compared with PAD participants with claudication, asymptomatic PAD participants have smaller plaque area and larger lumen area in the SFA. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00520312. |
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Authors:
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Mary M McDermott; Kiang Liu; James Carr; Michael H Criqui; Lu Tian; Debiao Li; Luigi Ferrucci; Jack M Guralnik; Christopher M Kramer; Chun Yuan; Melina Kibbe; William H Pearce; Jarett Berry; Walter McCarthy; Yihua Liao; Dongxiang Xu; Jennifer Orozco; Timothy J Carroll |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-03-24 |
Journal Detail:
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Title: Circulation. Cardiovascular imaging Volume: 4 ISSN: 1942-0080 ISO Abbreviation: Circ Cardiovasc Imaging Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-18 Completed Date: 2011-08-17 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 101479935 Medline TA: Circ Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 246-52 Citation Subset: IM |
Affiliation:
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Department of Medicine, Northwestern University’s Feinberg School of Medicine, Chicago, IL, USA. mdm608@northwestern.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00520312 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Ankle Brachial Index* Female Femoral Artery / pathology* Humans Leg / blood supply* Lipoproteins / blood Magnetic Resonance Imaging* Male Peripheral Arterial Disease / blood, diagnosis, pathology*, physiopathology Plaque, Atherosclerotic / pathology* Walking |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL083064-01A2/HL/NHLBI NIH HHS; R01 HL083064-02/HL/NHLBI NIH HHS; R01 HL083064-03/HL/NHLBI NIH HHS; R01 HL083064-04/HL/NHLBI NIH HHS; R01 HL088589-01A1/HL/NHLBI NIH HHS; R01-HL083064/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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