| Super-selective electrical stimulation of the left ventricle via a miniaturized magnetized stimulation wire: proof of concept study. | |
| | |
MedLine Citation:
|
PMID: 20731526 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Abstract Cardiac resynchronization therapy provides a treatment option for patients with congestive heart failure. Electrodes are usually advanced via the cardiac venous system (CVS). Placement is often hampered by small vessel diameter or tortuosity. The aim of this study was to develop and test a magnetized stimulation wire (MSW) capable of being navigated into small and tortuous CVS branches. Therefore, a conventional guide wire with a permanent magnet and a single stimulation electrode at its tip was coated with iridium oxide at the distal end and insulated except for the very tip (coating thickness: 500 nm, active uncoated area: 10 mm(2)). The MSW was designed to allow for a remote magnetic steering using a magnetic navigation system (MN) (Stereotaxis™). After in vitro testing of the electrical properties, the MSW was tested in an animal model (n=6 sheep): the MSW was placed in a CVS side branch and navigation characteristics of the MSW were determined. The effective (unipolar) pacing threshold was 4.9±2.4 V (at 2 ms pulse width). The rheobase was 1.89±0.44 V and the chronaxie time was 0.75±0.7 ms. The MSW could be navigated into small CVS branches with reasonable MN properties. This could allow stimulation at CVS sites currently not accessible for conventional stimulation catheters or electrodes. |
| | |
Authors:
|
Christian Knackstedt; Thomas Schimpf; Andreas Napp; Boerge Wessling; Christine Rothe; Karl Mischke; Uwe Schnakenberg; Patrick Schauerte |
Related Documents
:
|
8877496 - Effects of a 1.5-tesla static magnetic field on spermatogenesis and embryogenesis in mice. 15992236 - A critical review of randomized controlled trials of static magnets for pain relief. 16608486 - Orientation of culex mosquitoes to carbon dioxide-baited traps: flight manoeuvres and t... 20365876 - Magnetic-field decay of three interlocked flux rings with zero linking number. 2123236 - Cranial magnetic resonance imaging in chronic demyelinating polyneuropathy. 17413026 - Fibrillar and oligomeric beta-amyloid as distinct local biomarkers for alzheimer's dise... |
Publication Detail:
|
Type: Journal Article Date: 2010-08-23 |
Journal Detail:
|
Title: Biomedizinische Technik. Biomedical engineering Volume: 55 ISSN: 1862-278X ISO Abbreviation: Biomed Tech (Berl) Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1262533 Medline TA: Biomed Tech (Berl) Country: Germany |
Other Details:
|
Languages: eng Pagination: 285-90 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, RWTH Aachen University, Aachen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The nesting of search contexts within natural scenes: evidence from contextual cuing.
Next Document: A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of...