Document Detail


Super-selective basilar artery infusion of bevacizumab and cetuximab for multiply recurrent pediatric ependymoma.
MedLine Citation:
PMID:  22192550     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ependymoma is a central nervous system tumor associated with a poor prognosis due to limited efficacy of current medical treatment modalities, often resulting in multiple surgical re-resections with each tumor recurrence. As traditional chemotherapeutic regimens have proved unsuccessful in long-term control of subtotally resected ependymoma, other agents targeting the tumor microenvironement including the angiogenic factors supplying neovascularization have recently been used. Anti-angiogenic agents such as bevacizumab are routinely used in adult patients with recurrent glioma. Selective intra-arterial cerebral infusion (SIACI) of biological agents within tumor-supplying cerebral vasculature has recently been re-examined as a means to avoid the systemic side-effects associated with intravenous use of bevacizumab. This technical paper describes the first reported use of SIACI for delivery of two targeted biologic agents, bevacizumab and cetuximab in a pediatric patient utilizing the basilar artery to selectively administer the drugs to the tumor microenvironment. We believe this method for therapeutic delivery will both broaden treatment options and better refine treatment methodology as the multi-modality treatment approach often required to treat patients with pediatric ependymomas and other intracranial malignancies evolves.
Authors:
P Rajappa; J Krass; H A Riina; J A Boockvar; Jeffrey P Greenfield
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-12-16
Journal Detail:
Title:  Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences     Volume:  17     ISSN:  1591-0199     ISO Abbreviation:  Interv Neuroradiol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-23     Completed Date:  2012-03-01     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9602695     Medline TA:  Interv Neuroradiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  459-65     Citation Subset:  IM    
Affiliation:
Weill Cornell Brain Tumor Center, Department of Neurological Surgery, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Angiogenesis Inhibitors / administration & dosage*
Antibodies, Monoclonal / administration & dosage*
Antibodies, Monoclonal, Humanized / administration & dosage*
Antineoplastic Agents / administration & dosage*
Basilar Artery*
Brain Neoplasms / diagnosis,  drug therapy*
Drug Therapy, Combination
Ependymoma / diagnosis,  drug therapy*
Humans
Infusions, Intra-Arterial
Magnetic Resonance Imaging
Male
Neoplasm Recurrence, Local
Radiography, Interventional
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Antineoplastic Agents; 2S9ZZM9Q9V/bevacizumab; PQX0D8J21J/cetuximab
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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