| Super-resolution in PET imaging. | |
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MedLine Citation:
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PMID: 16468448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper demonstrates a super-resolution method for improving the resolution in clinical positron emission tomography (PET) scanners. Super-resolution images were obtained by combining four data sets with spatial shifts between consecutive acquisitions and applying an iterative algorithm. Super-resolution attenuation corrected PET scans of a phantom were obtained using the two-dimensional and three-dimensional (3-D) acquisition modes of a clinical PET/computed tomography (CT) scanner (Discovery LS, GEMS). In a patient study, following a standard 18F-FDG PET/CT scan, a super-resolution scan around one small lesion was performed using axial shifts without increasing the patient radiation exposure. In the phantom study, smaller features (3 mm) could be resolved axially with the super-resolution method than without (6 mm). The super-resolution images had better resolution than the original images and provided higher contrast ratios in coronal images and in 3-D acquisition transaxial images. The coronal super-resolution images had superior resolution and contrast ratios compared to images reconstructed by merely interleaving the data to the proper axial location. In the patient study, super-resolution reconstructions displayed a more localized 18F-FDG uptake. A new approach for improving the resolution of PET images using a super-resolution method has been developed and experimentally confirmed, employing a clinical scanner. The improvement in axial resolution requires no changes in hardware. |
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Authors:
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John A Kennedy; Ora Israel; Alex Frenkel; Rachel Bar-Shalom; Haim Azhari |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: IEEE transactions on medical imaging Volume: 25 ISSN: 0278-0062 ISO Abbreviation: IEEE Trans Med Imaging Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-10 Completed Date: 2006-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8310780 Medline TA: IEEE Trans Med Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 137-47 Citation Subset: IM |
Affiliation:
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Faculty of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Fluorodeoxyglucose F18 / diagnostic use Humans Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods* Imaging, Three-Dimensional / methods* Lung Neoplasms / radionuclide imaging* Phantoms, Imaging Positron-Emission Tomography / instrumentation, methods* Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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