Document Detail


'Super high-flux' or 'high cut-off' hemofiltration and hemodialysis.
MedLine Citation:
PMID:  20473007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently, 'super high-flux' (SHF) or 'high cut-off' (HCO) membranes have been developed to increase the clearance of inflammatory mediators. In the experimental and clinical settings, SHF/HCO membranes appear to achieve greater clearance of inflammatory cytokines than conventional high-flux membranes. SHF/HCO membranes also restore immune cell function, attenuate hemodynamic instability and decrease plasma IL-6 levels. Moreover, SHF/HCO membranes can eliminate larger late-phase inflammatory mediators such as HMGB-1. Although albumin sieving coefficients with SHF/HCO membranes are greater than with conventional high-flux membranes, the daily amount lost is limited and can be replaced. Hemodialysis with SHF/HCO membranes can also achieve similar cytokine removal to hemofiltration with acceptable albumin losses. When strategies for sepsis or systemic inflammation treatment target middle molecular mediators, both SHF/HCO hemofiltration and hemodialysis appear feasible and safe and require further clinical investigation.
Authors:
Toshio Naka; Michael Haase; Rinaldo Bellomo
Related Documents :
2085427 - High-permeable membranes and hypersensitivity-like reactions: role of dialysis fluid co...
6727077 - Studies on rabbit corneal permeability of local anesthetics (i).
18965937 - Atomic absorption spectrophotometric determination of gold with preconcentration by don...
21893027 - The bam machine: a molecular cooper.
15296367 - A comparison of human muscle temperature increases during 3-mhz continuous and pulsed u...
1387537 - Mitochondrial activity and heat-shock response during morphogenesis in the pathogenic f...
Publication Detail:
Type:  Journal Article; Review     Date:  2010-05-07
Journal Detail:
Title:  Contributions to nephrology     Volume:  166     ISSN:  1662-2782     ISO Abbreviation:  Contrib Nephrol     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513582     Medline TA:  Contrib Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  181-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Affiliation:
Department of Critical Care Medicine, Wakayama Medical University, Wakayama, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cytokines / blood,  isolation & purification
Hemodynamics
Hemofiltration / instrumentation*
Humans
Immunity
Inflammation Mediators / blood,  isolation & purification
Membranes, Artificial*
Renal Dialysis / instrumentation*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators; 0/Membranes, Artificial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Online CHDF system: excellent cost-effectiveness for continuous renal replacement therapy with high ...
Next Document:  Association between admission mean platelet volume and coronary patency after thrombolytic therapy f...