Document Detail

'Super high-flux' or 'high cut-off' hemofiltration and hemodialysis.
MedLine Citation:
PMID:  20473007     Owner:  NLM     Status:  MEDLINE    
Recently, 'super high-flux' (SHF) or 'high cut-off' (HCO) membranes have been developed to increase the clearance of inflammatory mediators. In the experimental and clinical settings, SHF/HCO membranes appear to achieve greater clearance of inflammatory cytokines than conventional high-flux membranes. SHF/HCO membranes also restore immune cell function, attenuate hemodynamic instability and decrease plasma IL-6 levels. Moreover, SHF/HCO membranes can eliminate larger late-phase inflammatory mediators such as HMGB-1. Although albumin sieving coefficients with SHF/HCO membranes are greater than with conventional high-flux membranes, the daily amount lost is limited and can be replaced. Hemodialysis with SHF/HCO membranes can also achieve similar cytokine removal to hemofiltration with acceptable albumin losses. When strategies for sepsis or systemic inflammation treatment target middle molecular mediators, both SHF/HCO hemofiltration and hemodialysis appear feasible and safe and require further clinical investigation.
Toshio Naka; Michael Haase; Rinaldo Bellomo
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-05-07
Journal Detail:
Title:  Contributions to nephrology     Volume:  166     ISSN:  1662-2782     ISO Abbreviation:  Contrib Nephrol     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513582     Medline TA:  Contrib Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  181-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Department of Critical Care Medicine, Wakayama Medical University, Wakayama, Japan.
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MeSH Terms
Cytokines / blood,  isolation & purification
Hemofiltration / instrumentation*
Inflammation Mediators / blood,  isolation & purification
Membranes, Artificial*
Renal Dialysis / instrumentation*
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators; 0/Membranes, Artificial

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