Document Detail

Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results.
MedLine Citation:
PMID:  18717957     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: UVA exposure of human skin mainly produces reactive oxygen species (ROS) leading to DNA, cell and tissue damage. It alters immune function, pigmentation and it is certainly responsible for a large part of photoaging changes. Moreover UVA is implicated in the etiology of several photodermatoses. As a consequence, to provide adequate protection, sunscreens or skin care products for daily use protective products need UVA absorbers combined with UVB ones. AIM: To assess the efficacy of sunscreens containing a broad-spectrum UVA absorber the Mexoryls SX or ecamsule and to compare formulations with and without it through a large number of clinical studies in human volunteers and patients. METHODS: The following assessments were conducted: *Prevention of excessive pigmentation induced by UV exposure in Caucasian and Asian skins using a method that measures pigmentation protection factors (PPF). *Efficacy against DNA damage by measurement of pyrimidine dimer formation and p53 protein accumulation. *Protection of immune system using delayed type hypersensitivity (DTH) reactions to recall antigens, isomerization of urocanic acid (UCA), alteration of Langerhans cells (LC) density, morphology and function. *Reduction of epidermal and dermal alterations induced by repeated UVA or UV solar simulated radiation (SSR) using histology or immunohistology. *Prevention of the polymorphous light eruption (PMLE) in patients prone to develop this disease. RESULTS: Mexoryls SX-containing formulations showed a dose-dependent level of protection against pigmentation. For a same sun protection factor (SPF) the higher the UVA protection was, the higher was the PPF. Pyrimidine dimer formation and p53 accumulation were significantly reduced by formulations with Mexoryls SX. In the studies looking at the suppression of DTH reactions to recall antigens by the different UV spectra, the LC alterations and the cis UCA formation, Mexoryls SX formulations always showed a higher protective potency than sunscreen without it even when the protection against erythema was similar (products with same SPF). Mexoryls SX formulations also prevented or significantly decreased to minimal, ferritin, tenascin and lysozyme expression induced by repeated UVA or SSR exposure. It also reduced the enhancement of collagenase 2 mRNA expression induced by SSR exposure. Finally PMLE study demonstrated that UVA protection was essential for the prevention of this photodermatose. CONCLUSION: Mexoryls SX formulated in sunscreens or daily use products have been shown to be an effective UV absorber, leading to an increased efficacy of these products against a large number of biological damage induced by UVA, SSR or sun exposure.
Anny Fourtanier; Dominique Moyal; Sophie Seité
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Photodermatology, photoimmunology & photomedicine     Volume:  24     ISSN:  1600-0781     ISO Abbreviation:  Photodermatol Photoimmunol Photomed     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-22     Completed Date:  2008-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013641     Medline TA:  Photodermatol Photoimmunol Photomed     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  164-74     Citation Subset:  IM    
L'Oréal Recherche, Clichy, France.
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MeSH Terms
Bornanes / chemistry,  pharmacology,  therapeutic use*
Hypersensitivity, Delayed / drug therapy,  etiology
Immune Tolerance / drug effects,  radiation effects
Photosensitivity Disorders / prevention & control*
Pyrimidine Dimers / metabolism
Radiation Dosage
Radiation Injuries / prevention & control*
Skin / drug effects*,  immunology,  metabolism,  radiation effects*
Skin Aging* / drug effects,  pathology,  radiation effects
Skin Pigmentation / drug effects,  radiation effects
Sulfonic Acids / chemistry,  pharmacology,  therapeutic use*
Sunscreening Agents / chemistry,  pharmacology,  therapeutic use*
Tumor Suppressor Protein p53 / metabolism
Ultraviolet Rays / adverse effects*,  classification
Reg. No./Substance:
0/Bornanes; 0/Pyrimidine Dimers; 0/Sulfonic Acids; 0/Sunscreening Agents; 0/Tumor Suppressor Protein p53; 0/terephthalylidene dicamphor sulfonic acid

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