| Sunitinib-induced Nephrotic Syndrome in Association with Drug Response in a Patient with Xp11.2 Translocation Renal Cell Carcinoma. | |
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MedLine Citation:
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PMID: 21965162 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We report the case of a patient with metastatic renal cell carcinoma with Xp11.2 translocation/transcription factor E3 (TFE3) gene fusion who had presented with sunitinib-induced nephrotic syndrome in association with favorable and durable treatment response. The nephrotic syndrome was managed successfully by discontinuing sunitinib and symptomatic treatment. The 27-year-old female patient presenting with right upper abdominal pain was diagnosed with Xp11.2 translocation renal cell carcinoma on the right side with multiple pulmonary and hepatic metastases. She underwent radical nephrectomy and took a daily dose of 37.5 mg sunitinib. Partial response to sunitinib was achieved and maintained for 5 months, but when nephrotic syndrome occurred, drug intake was discontinued. The nephrotic syndrome gradually resolved around 2 months after discontinuation of sunitinib and medical management. Our case highlighted the favorable response of a particular non-clear cell type renal cell carcinoma to sunitinib and the specific toxicity associated with the antiangiogenic effect of sunitinib. |
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Authors:
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Yao-Chung Liu; Peter Mu-Hsin Chang; Chun-Yu Liu; Chih-Yu Yang; Ming-Han Chen; Chin-Chen Pan; Ming-Huang Chen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-29 |
Journal Detail:
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Title: Japanese journal of clinical oncology Volume: - ISSN: 1465-3621 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0313225 Medline TA: Jpn J Clin Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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