| Sunitinib in metastatic renal cell carcinoma: recommendations for management of noncardiovascular toxicities. | |
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MedLine Citation:
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PMID: 21490127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The multitargeted tyrosine-kinase inhibitor sunitinib has emerged as one of the standards of care for good- and intermediate-risk metastatic renal cell carcinoma. Although generally associated with acceptable toxicity, sunitinib exhibits a novel and distinct toxicity profile that requires monitoring and management. Fatigue, diarrhea, anorexia, oral changes, hand-foot syndrome and other skin toxicity, thyroid dysfunction, myelotoxicity, and hypertension seem to be the most common and clinically relevant toxicities of sunitinib. Drug dosing and treatment duration are correlated with response to treatment and survival. Treatment recommendations for hypertension have been published but, currently, no standard guidelines exist for the management of noncardiovascular side effects. To discuss the optimal management of noncardiovascular side effects, an international, interdisciplinary panel of experts gathered in November 2009. Existing literature on incidence, severity, and underlying mechanisms of side effects as well as on potential treatment options were carefully reviewed and discussed. On the basis of these proceedings and the thorough review of the existing literature, recommendations were made for the monitoring, prevention, and treatment of the most common noncardiovascular side effects and are summarized in this review. The proactive assessment and consistent and timely management of sunitinib-related side effects are critical to ensure optimal treatment benefit by allowing appropriate drug dosing and prolonged treatment periods. |
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Authors:
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Christian Kollmannsberger; Georg Bjarnason; Patrick Burnett; Patricia Creel; Mellar Davis; Nancy Dawson; Darren Feldman; Suzanne George; Jerome Hershman; Thomas Lechner; Amy Potter; Eric Raymond; Nathaniel Treister; Laura Wood; Shenhong Wu; Ronald Bukowski |
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Publication Detail:
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Type: Journal Article; Review Date: 2011-04-13 |
Journal Detail:
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Title: The oncologist Volume: 16 ISSN: 1549-490X ISO Abbreviation: Oncologist Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-18 Completed Date: 2011-09-13 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 9607837 Medline TA: Oncologist Country: United States |
Other Details:
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Languages: eng Pagination: 543-53 Citation Subset: IM |
Affiliation:
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Division of Medical Oncology, BCCA Vancouver Cancer Centre, University of British Columbia, 600 West 10th Avenue, Vancouver, BC V5Z 4E6, Canada. ckollmannsberger@bccancer.bc.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asthenia
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chemically induced,
therapy Carcinoma, Renal Cell / drug therapy*, secondary Diarrhea / chemically induced, therapy Dose-Response Relationship, Drug Erythema / chemically induced, therapy Exanthema / chemically induced, therapy Fatigue / chemically induced, therapy Humans Hypothyroidism / chemically induced, therapy Indoles / administration & dosage, adverse effects*, therapeutic use Kidney Neoplasms / drug therapy*, pathology Practice Guidelines as Topic* Protein Kinase Inhibitors / administration & dosage, adverse effects*, therapeutic use Pyrroles / administration & dosage, adverse effects*, therapeutic use Standard of Care |
| Chemical | |
Reg. No./Substance:
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0/Indoles; 0/Protein Kinase Inhibitors; 0/Pyrroles; 0/sunitinib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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