| Sun-induced life-threatening lupus nephritis. | |
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MedLine Citation:
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PMID: 17893968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Photosensitivity is a widely known characteristic of both cutaneous and systemic lupus erythematosus (LE). However, sun-induced organ involvement is rarely reported in LE. We describe a 34-year-old woman who had been in complete remission of systemic LE for more than 8 years without treatment. After sunbathing, she developed acute sunburn followed by cutaneous LE in sun-exposed areas. Six weeks later, a lupus nephritis was diagnosed and high serum levels of antidouble-stranded (ds) DNA and anti-Ro/SSA antibodies were detected. Treatment with systemic cyclophosphamide and prednisolone led to septicemia requiring assisted ventilation for more than 2 weeks and repeated hemodialysis. Clinical remission was achieved 3 months later by the use of prednisolone and mycophenolate mofetile. Meanwhile, mild proteinuria persisted, anti-dsDNA antibodies normalized. We hypothesize that the sunburn-induced keratinocyte necrosis/apoptosis exposed intracellular antigens as trigger for the generation of autoantibodies that finally mediated immune-complex nephritis. The patient highlights the impact of UV light not only on skin but also on internal organ involvement in LE. |
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Authors:
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Enno Schmidt; Hans-Peter Tony; Eva-Bettina Bröcker; Christian Kneitz |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1108 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-09-25 Completed Date: 2007-10-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 35-40 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of Würzburg, Würzburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Antinuclear / blood Female Humans Lupus Nephritis / blood, etiology*, physiopathology Photosensitivity Disorders / blood, physiopathology* Sunburn Sunlight / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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