Document Detail

Sun exposure as a risk factor for nuclear cataract.
MedLine Citation:
PMID:  14569187     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cataracts are the leading cause of blindness and visual impairment throughout the world. An association of sun exposure with cortical cataract has been well established, but the association with nuclear cataract remains unclear. METHODS: This case-control study was nested within the Nambour (Australia) Trial of Skin Cancer Prevention conducted between 1992 and 1996. We compared 195 cases who had a nuclear opacity of grade 2.0 or greater with 159 controls. Structured questionnaires were used to ascertain lifetime sun exposure history, eyeglasses and sunglasses use, and potentially confounding variables such as education and smoking. RESULTS: There was a strong positive association of occupational sun exposure between the ages of 20 and 29 years with nuclear cataract (odds ratio = 5.9; 95% confidence interval = 2.1-17.1). Exposure later in life resulted in weaker associations. Wearing sunglasses, particularly during these early years, afforded some protective effect. CONCLUSIONS: This study provides new evidence to support a link between sun exposure and nuclear cataract. Risk was highest among those with high sun exposure at younger ages.
Rachel E Neale; Jennifer L Purdie; Lawrence W Hirst; Adèle C Green
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  14     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-21     Completed Date:  2004-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  707-12     Citation Subset:  IM    
Population Studies and Human Genetics Division, Queensland Institute of Medical Research, Brisbane, Australia.
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MeSH Terms
Case-Control Studies
Cataract / classification,  etiology*
Environmental Exposure / adverse effects*
Health Status Indicators
Middle Aged
Occupational Exposure / adverse effects
Risk Factors
Sunlight / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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