Document Detail


Sumo paralogs: redundancy and divergencies .
MedLine Citation:
PMID:  23277067     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Although sharing a common conjugation pathway, SUMO1, SUMO2/3 and SUMO4 seem to play preferential roles in the cell. Recently, many regulatory mechanisms contributing to SUMO paralogs specific modification have emerged. SUMO enzymes can discriminate between SUMO paralogs at both conjugation and deconjugation levels. Moreover, many substrates possess characteristics that promote their preference for different SUMO family members. A better knowledge of the mechanisms promoting SUMO specific modification will improve our understanding of the functions of SUMO paralogs in distinct cellular pathways.
Authors:
Simona Citro; Susanna Chiocca
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Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  5     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  544-53     Citation Subset:  IM    
Affiliation:
Department of Experimental Oncology, European Institute of Oncology at the IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy.
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