| Summary of clinical trials with zafirlukast. | |
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MedLine Citation:
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PMID: 9647606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Zafirlukast is an orally active and selective cysteinyl leukotriene (cysLT) receptor antagonist. In humans, zafirlukast antagonized the effects of exogenously administered LTD4 and cysLTs released endogenously in response to physical and chemical stimuli. Zafirlukast antagonized LTD4-induced bronchoconstriction, with effects still evident 12 h after drug administration. In clinical models of asthma, zafirlukast inhibited bronchospasm after allergen or exercise challenge in patients with asthma. In multicenter trials in patients with chronic, stable asthma, zafirlukast reduced asthma symptoms, decreased as-needed beta-agonist use, and improved pulmonary function without increasing the number of adverse events. Zafirlukast also exhibited evidence of an anti-inflammatory effect in the lung in preliminary studies involving segmental antigen challenge. The results from these clinical trials demonstrate that zafirlukast is effective and safe for the prophylactic treatment of asthma. |
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Authors:
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W J Calhoun |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 157 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-07-09 Completed Date: 1998-07-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S238-45; discussion S245-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pennsylvania 15261, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Asthmatic Agents
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pharmacology,
therapeutic use* Anti-Inflammatory Agents, Non-Steroidal / pharmacology Asthma / drug therapy*, etiology, metabolism, physiopathology Bronchoconstriction / drug effects* Clinical Trials as Topic Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Drug Interactions Humans Leukotriene Antagonists* Multicenter Studies as Topic Tosyl Compounds / pharmacology, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Asthmatic Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Leukotriene Antagonists; 0/Tosyl Compounds; 107753-78-6/zafirlukast |
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