| Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects. | |
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MedLine Citation:
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PMID: 18540871 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arteriovenous anastomoses (AVAs) may open up during migraine attacks. In studies with anaesthetized and bilaterally vagosympatectomized pigs, triptans reduce AVA blood flow and increase the arteriovenous O2 difference (AVDO2). To investigate whether subcutaneous sumatriptan 6 mg could induce changes in the AVDO2, we measured the AVDO2 in the external jugular vein in healthy subjects. We also measured the AVDO2 in the internal jugular and cubital veins. There were no changes in AVDO2 after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system. |
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Authors:
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T Wienecke; J M Hansen; J Petersen; K S Olsen; M Ashina; P Tfelt-Hansen |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-06 |
Journal Detail:
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Title: Cephalalgia : an international journal of headache Volume: 28 ISSN: 1468-2982 ISO Abbreviation: Cephalalgia Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-30 Completed Date: 2008-12-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: England |
Other Details:
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Languages: eng Pagination: 1081-5 Citation Subset: IM |
Affiliation:
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Danish Headache Centre and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteriovenous Anastomosis / drug effects* Female Humans Injections, Subcutaneous Jugular Veins / drug effects* Male Oxygen / blood* Reference Values Regional Blood Flow / drug effects Serotonin Agonists / administration & dosage* Sumatriptan / administration & dosage* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Agonists; 103628-46-2/Sumatriptan; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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