Document Detail

Sulphydryl and disulphide groups in normal and irradiated epidermis.
MedLine Citation:
PMID:  1084864     Owner:  NLM     Status:  MEDLINE    
The distribution of sulphydryl (SH) and disulphide (SS) groups in normal and irradiated epidermis of newly-born rats was studied by microspectrophotometric quantitation of the Mercury-Orange reaction. In order to obtain information on (1) the total content of both groups within the different strata of the epithelium, and (2) the mean SH and SS concentration, which is an indicator of the density of these groups per unit of tissue. The content of both groups increased in relation to the extent of irradiated area, whereas there was a decrease in the mean concentration. The increase in content of SH and SS would lead to augmented production of keratin substance previously reported in irradiated epithelia, coincidentally with an acanthotic response. The decrease in concentration of SH and SS indicates a destruction of these groups at cellular level, which may be due to membrane alterations. The findings would explain an acceleration of the keratinizing process together with modifications, both in quality and in quantity, in the horny substance.
A C Frasch; M E Itoiz; H E Volco; R L Cabrini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation biology and related studies in physics, chemistry, and medicine     Volume:  29     ISSN:  0020-7616     ISO Abbreviation:  Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-09-25     Completed Date:  1976-09-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374725     Medline TA:  Int J Radiat Biol Relat Stud Phys Chem Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  301-9     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Disulfides / analysis*
Radiation Effects*
Skin / analysis,  radiation effects*
Sulfhydryl Compounds / analysis*
Reg. No./Substance:
0/Disulfides; 0/Sulfhydryl Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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