| Sulphation of the flavonoids quercetin and catechin by rat liver. | |
| | |
MedLine Citation:
|
PMID: 1776264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. The isolated perfused rat liver forms three sulphated metabolites from each of the flavonoids, quercetin and catechin: these are secreted into the bile and the perfusate. 2. Quercetin gives two double conjugates, containing sulphate and glucuronic acid, and one sulphate: catechin gives one such double conjugate and two sulphates. 3. This sulphation is not inhibited by 60 microM 2,6-dichloro-4-nitrophenol which almost completely inhibits the sulphation of harmol in this perfused liver system. 4. The sulphation of harmol by the perfused liver is not inhibited by the flavonoids. 5. Unfractionated sulphotransferases from rat liver catalyse sulphate conjugation of quercetin and catechin in vitro by a reaction inhibited by pentachlorophenol or dichloronitrophenol: the flavonoids inhibit the sulphation of 4-nitrophenol by this system. 6. The results with the two systems are discussed and shown to be compatible. |
| | |
Authors:
|
N A Shali; C G Curtis; G M Powell; A B Roy |
Related Documents
:
|
8020534 - Cimetidine and omeprazole do not affect cyclosporine disposition by the rat liver. 1113014 - Nitrogen metabolism in the perfused cirrhotic liver of the rat. 3973514 - Regulated biosynthesis and divergent metabolism of three forms of hepatic apolipoprotei... 15144734 - Hepatic disposition of cyclosporine a in isolated perfused rat livers. 11746864 - Inhibition of azoxymethane-induced aberrant crypt foci formation in rat colorectum by w... 20051484 - Differential effect of l-cysteine in isolated whole-bladder preparations from neonatal ... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 21 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 1991 Jul |
Date Detail:
|
Created Date: 1992-03-04 Completed Date: 1992-03-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 881-93 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry, University of Wales, College of Cardiff, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bile / metabolism Catechin / metabolism* Chromatography, Thin Layer Glucuronidase / diagnostic use Harmine / analogs & derivatives, metabolism Hydrolysis Liver / drug effects, metabolism* Nitrophenols / pharmacology Perfusion Quercetin / metabolism* Rats Sulfates / metabolism Sulfur Radioisotopes / diagnostic use |
| Chemical | |
Reg. No./Substance:
|
0/Nitrophenols; 0/Sulfates; 0/Sulfur Radioisotopes; 117-39-5/Quercetin; 154-23-4/Catechin; 442-51-3/Harmine; 487-03-6/harmol; 618-80-4/2,6-dichloro-4-nitrophenol; EC 3.2.1.31/Glucuronidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Absorption and disposition of epithiosteroids in rats (2): Avoidance of first-pass metabolism of mep...
Next Document: Comparison of the effects of inducers of cytochrome P450 on Mongolian gerbil and rat hepatic microso...