Document Detail


Sulphamethoxazole acetylation in fast and slow acetylators.
MedLine Citation:
PMID:  2338369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acetylation of sulphamethoxazole was studied in 22 subjects previously phenotyped with sulphadimidine. Sulphamethoxazole and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples. Percentage of plasma acetylated-sulphamethoxazole did not correlate with the percentage of urinary acetylated-sulphamethoxazole. There was also no correlation between the percentage of acetylated-sulphadimidine and percentage of acetylated-sulphamethoxazole in plasma. The finding suggest that the acetylation of sulphamethoxazole has no predictive value in determining acetylator status.
Authors:
A Bozkurt; N E Basci; A Isimer; M Tuncer; R Erdal; S O Kayaalp
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  28     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-06-20     Completed Date:  1990-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  164-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Hacettepe, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Acetylation
Adult
Aged
Female
Humans
Male
Middle Aged
Phenotype
Sulfamethazine / metabolism
Sulfamethoxazole / blood,  metabolism*,  urine
Chemical
Reg. No./Substance:
57-68-1/Sulfamethazine; 723-46-6/Sulfamethoxazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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