Document Detail

Sulodexide versus calcium heparin in the medium-term treatment of deep vein thrombosis of the lower limbs.
MedLine Citation:
PMID:  9313630     Owner:  NLM     Status:  MEDLINE    
Thirty adult patients with distal, monolateral deep vein thrombosis of the lower limbs were randomly treated for sixty days either with subcutaneous Ca-Heparin or with Sulodexide, administered IM for ten days and orally for fifty days. The thrombus accretion above the knee, the venous pressures of the affected leg, the clinical symptomatology, and some laboratory coagulative tests were monitored throughout the administration period. Local tolerability of the two treatments was also evaluated. The two applied treatments evidenced a net antithrombotic activity, preventing thrombus accretion above the knee, improving with the same efficacy the venous pressures in the affected legs, and similarly reducing clinical symptoms, with a quick and statistically significant trend toward normalization. Blood fibrinogen was significantly lowered by both drugs, while only Ca-heparin yielded a prolongation of activated partial thromboplastin time. Local tolerability of treatments was better for the mainly oral Sulodexide administrations, while subcutaneous Ca-heparin often induced small, though transient, hematomas.
A Pinto; S Corrao; D Galati; S Arnone; A Licata; G Parrinello; T Maniscalchi; G Licata
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Angiology     Volume:  48     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-31     Completed Date:  1997-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  805-11     Citation Subset:  IM    
Institute of Internal Medicine, University of Palermo, Italy.
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MeSH Terms
Fibrinolytic Agents / administration & dosage,  therapeutic use*
Glycosaminoglycans / administration & dosage,  therapeutic use*
Heparin / therapeutic use*
Middle Aged
Thrombophlebitis / drug therapy*
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Glycosaminoglycans; 37270-89-6/calcium heparin; 58915-48-3/glucuronyl glucosamine glycan sulfate; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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