Document Detail


Sulindac sulfide inhibits the proliferation of colon cancer cells: diminished expression of the proliferation markers PCNA and Ki-67.
MedLine Citation:
PMID:  9149129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the effect of sulindac sulfide (SS), which reduces cell number and induces apoptosis in cultured colon cancer cells (CCCs), on expression of the proliferation markers PCNA and Ki-67 in HT-29 and HCT-15 CCCs; only the former express cyclooxygenases. DNA content and PCNA/Ki-67 expression were analyzed by bivariate flow cytometry. SS inhibited cell proliferation, determined by the reduced expression of PCNA and Ki-67, roughly by half at 72 h, and induced apoptosis (accounting for about two-thirds and one-third of the reduction in cell number, respectively). A similar effect of SS occurred in HT-29 and HCT-15 CCCs, and also in non-colonic cells, indicating that this rather general effect of SS on cultured cells is not dependent on inhibition of prostaglandin synthesis.
Authors:
L Qiao; S J Shiff; B Rigas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  115     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-04     Completed Date:  1997-06-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  229-34     Citation Subset:  IM    
Affiliation:
Department of Medicine, Cornell University Medical College, New York, NY 10021, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy*,  metabolism
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects
Cell Count / drug effects
Cell Cycle / drug effects
Cell Division / drug effects
Colonic Neoplasms / drug therapy*,  metabolism
HL-60 Cells / drug effects,  metabolism
HT29 Cells / drug effects,  metabolism
Humans
Ki-67 Antigen / biosynthesis*,  metabolism
Proliferating Cell Nuclear Antigen / biosynthesis*,  metabolism
Sulindac / analogs & derivatives*,  pharmacology
Tumor Markers, Biological / biosynthesis*,  metabolism
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Ki-67 Antigen; 0/Proliferating Cell Nuclear Antigen; 0/Tumor Markers, Biological; 32004-67-4/sulindac sulfide; 38194-50-2/Sulindac

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