Document Detail


Sulindac in familial adenomatous polyposis: evaluation by nuclear morphometry.
MedLine Citation:
PMID:  11419555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To find out if nuclear morphometry is a useful indicator of prognosis in patients with familial adenomatous polyposis (FAP) before and after treatment with sulindac. DESIGN: Open study. SETTING: Teaching hospital, Spain. SUBJECTS: 29 patients (17 women and 12 men) with FAP who had been treated by colectomy. There were two control groups: 17 people with healthy rectal mucosa and 10 patients with colorectal cancer. INTERVENTIONS: The 29 patients with FAP were treated with sulindac 150 mg orally twice daily for 6 months. MAIN OUTCOME MEASURES: Results of histological examination of biopsy specimens and nuclear morphometry. RESULTS: Before treatment, all patients with FAP had nuclei of cells in the rectal mucosa that were intermediate in size between those in healthy mucosa (small nuclei) and those in cancer (large nuclei). After 6 months' treatment with sulindac the patients with FAP no longer had any polyps and the size of the nuclei was similar to those in healthy mucosa. Only 1 patient failed to respond, and in this patient one of the polyps subsequently became malignant. CONCLUSIONS: Nuclear morphometry may be useful in identifying patients with FAP who are at high risk of malignant degeneration.
Authors:
F Fernández-López; R Conde-Freire; C Cadarso-Suárez; J García-Iglesias; J L Puente-Domínguez; J Potel-Lesquereux
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European journal of surgery = Acta chirurgica     Volume:  167     ISSN:  1102-4151     ISO Abbreviation:  Eur J Surg     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-22     Completed Date:  2001-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9105264     Medline TA:  Eur J Surg     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  375-81     Citation Subset:  IM    
Affiliation:
General Surgery Department, Hospital Clínico Universitario, Santiago de Compostela, Spain. cifern@usc.es
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MeSH Terms
Descriptor/Qualifier:
Adenomatous Polyposis Coli / drug therapy,  pathology*,  surgery
Adolescent
Adult
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Colorectal Neoplasms / pathology
Female
Humans
Intestinal Mucosa / pathology*
Male
Rectum / pathology*
Sulindac / therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 38194-50-2/Sulindac

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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