Document Detail

Sulfur dioxide induced airway hyperreactivity in allergic sheep.
MedLine Citation:
PMID:  7342777     Owner:  NLM     Status:  MEDLINE    
The effects of a four-hour exposure (via a Plexiglas hood) to sulfur dioxide (SO2) on airway reactivity was studied in both normal and allergic conscious sheep. Allergic sheep were defined as animals in whom inhalation of Ascaris suum extract resulted in an increase in mean pulmonary flow resistance (RL). Airway reactivity (delta RL) was assessed by measuring the increase in RL after 18 breaths of 0.25% carbachol, from an initial value obtained after 18 breaths of buffered saline. RL and delta RL were determined prior to, immediately after and 24 hours following SO2 exposure in three groups of sheep: six normal sheep exposed to 5 ppm SO2 (group A); six normal sheep exposed to 10 ppm SO2 (group B) and seven allergic sheep exposed to 5 ppm SO2 (group C). RL was not affected by SO2 exposure in any group but both groups B and C showed increases in delta RL 24 hours after exposure. Since the increase in delta RL was greater in group C than in either groups A or B, we conclude that allergic sheep have enhanced susceptibility to the injurious airway effects of SO2.
W M Abraham; W Oliver; M J Welker; M King; G A Chapman; L Yerger; D R Maurer; M Sielczak; A Wanner; M A Sackner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  1     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  1980  
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  383-90     Citation Subset:  IM    
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MeSH Terms
Airway Resistance / drug effects*
Bronchi / drug effects,  pathology
Bronchial Provocation Tests
Respiratory Hypersensitivity / physiopathology*
Sulfur Dioxide / pharmacology*
Grant Support
Reg. No./Substance:
7446-09-5/Sulfur Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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