| Sulfisoxazole chemoprophylaxis for frequent otitis media. | |
| | |
MedLine Citation:
|
PMID: 6601256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sulfisoxazole, 75 mg/kg/d in two divided doses for 3 months, was administered in a double-blind placebo crossover study to 35 children aged 6 months to 5 years who had frequent recurring episodes of otitis media. There was a 40% reduction in the rate of otitis media among patients receiving sulfisoxazole compared with those receiving placebo (0.25 v 0.42 episode per patient-month) which did not depend on age, sex, season, or several other factors. Using a randomized order, among patients who received placebo first, there was a 64% reduction on sulfisoxazole therapy compared with placebo (0.20 v 0.56 episode per patient-month). In this subgroup, there was significant improvement in eustachian tube function according to serial tympanograms. In the patients who received sulfisoxazole first, the rate of acute otitis remained low on placebo (0.28 v 0.30 episode per patient-month), and tympanogram patterns continued to improve after discontinuation of the active drug. These differences suggest a carry-over effect from the benefits of chemoprophylaxis. There was no significant difference in the species or sensitivity patterns of bacteria isolated from patients receiving sulisoxazole or placebo. Sulfisoxazole chemoprophylaxis appears to be safe and effective in significantly reducing episodes of otitis media and improving tympanogram patterns. |
| | |
Authors:
|
T E Liston; W S Foshee; W D Pierson |
Related Documents
:
|
329786 - Phenothiazine-induced ecg abnormalities: effect of a glucose load. 11167966 - Topical sucralfate in the management of peristomal skin disease: an open study. 14707396 - Efficacy and tolerability of pantoprazole compared with misoprostol for the prevention ... 17426546 - Use of low-intensity pulsed ultrasound for posttraumatic nonunions of the tibia: a revi... 3421866 - A clinical study of reinke's edema. 23027226 - Bis-guided anesthesia decreases postoperative delirium and cognitive decline. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Pediatrics Volume: 71 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1983 Apr |
Date Detail:
|
Created Date: 1983-05-05 Completed Date: 1983-05-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 524-30 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acoustic Impedance Tests Child, Preschool Double-Blind Method Eustachian Tube / drug effects Female Haemophilus influenzae / isolation & purification Humans Infant Male Otitis Media / microbiology, prevention & control* Random Allocation Recurrence Streptococcus pneumoniae / isolation & purification Sulfisoxazole / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
127-69-5/Sulfisoxazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Short communication. Photochemical reactions of riboflavin: covalent binding to DNA and to poly (dA)...
Next Document: Dyskeratosis congenita: two examples of this multisystem disorder.