Document Detail

Sulfidopeptide leukotrienes contribute to human alveolar macrophage activation in asthma.
MedLine Citation:
PMID:  1850529     Owner:  NLM     Status:  MEDLINE    
The mechanism involved in amplification of the local inflammatory process, characteristic of asthma, was investigated through the role of human alveolar macrophages. During asthma attacks, mast cells and eosinophils are known to be activated in order to release arachidonic acid derived inflammation mediators such as sulfidopeptide leukotrienes. It is now known that these metabolites, particularly leukotriene C4, are present in bronchoalveolar lavage from asthmatic patients. Alveolar macrophages, recovered by bronchoalveolar lavage and purified by adherence, are able to transform LTC4 into LTE4. In four asthmatic patients with severe local inflammation as determined by fibrobronchoscopy, these phagocytes, incubated in the presence of LTC4, also generated LTB4 and 5-HETE, which remained within the cells. These preliminary results are discussed relative to amplification of the local process, involving cooperation between the different cells involved in airway responsiveness.
C Chavis; P Godard; F B Michel; A Crastes de Paulet; M Damon
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  42     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-05-28     Completed Date:  1991-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
Clinique des Maladies Respiratoires, Hôpital l'Aiguelongue, Montpellier, France.
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MeSH Terms
Asthma / metabolism*,  physiopathology
Hydroxyeicosatetraenoic Acids / metabolism
Leukotriene B4 / metabolism
Leukotrienes / metabolism*
Macrophage Activation
Macrophages / metabolism*
Pulmonary Alveoli / metabolism*
SRS-A / metabolism
Reg. No./Substance:
0/Hydroxyeicosatetraenoic Acids; 0/Leukotrienes; 0/SRS-A; 71160-24-2/Leukotriene B4; 72255-35-7/5-hydroxy-6,8,11,14-eicosatetraenoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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