Document Detail

Sulfhydryl-dependent thermal aggregation of human gamma globulin: augmentation by hyaluronic acid.
MedLine Citation:
PMID:  46754     Owner:  NLM     Status:  MEDLINE    
Hyaluronic acid (4 mg/ml) augmented elevenfold the copper-catalyzed (7 muM) thermal (63 degrees C, 2 hours) aggregation of human gamma globulin (2 mg/ml) in 0.075 M phosphate buffer, pH 7.4. Almost no augmentation of aggregation occurred with hyaluronidase-treated hyaluronate. Hyaluronate-augmented copper-catalyzed thermal aggregation was inhibited by L-histidine, gold thiomalate, N-ethylmaleimide, p-chloromercuribenzoic acid, and ethylenediaminetetraacetic acid. Together with previous reports of a decreased blood histidine concentration in rheumatoid arthritis, these studies provide a possible explanation for the affinity of this disease for joints.
D A Gerber
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  18     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:    1975 Jan-Feb
Date Detail:
Created Date:  1975-05-09     Completed Date:  1975-05-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  AIM; IM    
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MeSH Terms
Chemical Precipitation
Chloromercuribenzoates / pharmacology
Copper / pharmacology
Depression, Chemical
Edetic Acid / pharmacology
Ethylmaleimide / pharmacology
Gold Sodium Thiomalate / pharmacology
Hot Temperature*
Hyaluronic Acid / pharmacology*
Sulfhydryl Compounds / pharmacology*
Reg. No./Substance:
0/Chloromercuribenzoates; 0/Sulfhydryl Compounds; 0/gamma-Globulins; 12244-57-4/Gold Sodium Thiomalate; 128-53-0/Ethylmaleimide; 60-00-4/Edetic Acid; 7440-50-8/Copper; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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