Document Detail

Sulfhydryl-Dependent Dimerization and cGMP-Mediated Vasodilatation.
MedLine Citation:
PMID:  23232843     Owner:  NLM     Status:  Publisher    
ABSTRACT: Sulfhydryl-dependent formation of interprotein disulfide bonds in response to physiological oxidative stimuli is emerging as an important mechanism in the regulation of various biological activities. Soluble guanylyl cyclase (sGC) and cGMP-dependent protein kinase (PKG) are key enzymes for actions caused by cGMP-elevating agents including nitric oxide (NO). Both sGC and PKG are dimers. The dimerization of sGC is obligatory for its activity while the dimerization of PKG improving its signaling efficacy. sGC dimerization is decreased by endogenous and exogenous thiol reductants, associated with reduced cGMP elevation and attenuated vasodilatation to NO. The dimerization of PKG Iα is increased by oxidative stress, coincident with improved PKG signaling and augmented vasodilatation to NO. In coronary arteries the dimerizations and activities of sGC and PKG are increased by hypoxia, accompanied by enhanced relaxation induced by NO. In contrast, the dimerizations and activities of these enzymes and NO-induced relaxation of pulmonary arteries are reduced by hypoxia. These opposite effects may result from divergent changes in the redox status of cytoplasmic NADPH between coronary and pulmonary arteries in response to hypoxia.
Dou Dou; Xiaoxu Zheng; Lei Ying; Liping Ye; Yuansheng Gao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-7
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China 2Department of Medicine,University of Maryland School of Medicine, Baltimore MD, USA 3Department of Pathophysiology, Wenzhou Medical College,Wenzhou, Zhejiang, China 4Department of pathophysiology, Liaoning Medical University, Jinzhou, Liaoning, China.
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