| Sulfenic acids as reactive intermediates in xenobiotic metabolism. | |
| | |
MedLine Citation:
|
PMID: 20869346 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Sulfenic acid reactive intermediates are formed during the oxidation of cysteine residues of proteins and play key roles in enzyme catalysis, redox homeostasis and regulation of cell signalling. However few data are presently available on the formation and fate of sulfenic acids as reactive intermediates during the metabolism of xenobiotics. This article is a review of the xenobiotic metabolism situations in which the intermediate formation of a sulfenic acid has been reported. Formation of these intermediates has been either proposed on the basis of the isolation of products possibly deriving from sulfenic acids or shown after trapping of the sulfenic acid by specific nucleophiles. This review indicates the different mechanisms by which a sulphur-containing xenobiotic can be metabolized with the intermediate formation of a sulfenic acid. It also indicates the different possible fates of these sulfenic acids that have been reported in the literature. Finally, it discusses the possible implications of the formation of xenobiotic-derived sulfenic acid reactive metabolites in pharmacology and toxicology. |
| | |
Authors:
|
Daniel Mansuy; Patrick M Dansette |
Related Documents
:
|
15976866 - Internally stabilized selenocysteine derivatives: syntheses, 77se nmr and biomimetic st... 9873646 - 4-phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase. 6424956 - Synthesis of dinitrophenyl derivatives of 3-o-fatty acyl esters of serine and threonine. 19725506 - Facile entry into triazole fused heterocycles via sulfamidate derived azido-alkynes. 3338356 - Effect of cigarette smoking on extent of acid-secreting area and intestinal metaplasia ... 17150706 - Development of real time imaging of specific messenger rna in a living cell using artif... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-01 |
Journal Detail:
|
Title: Archives of biochemistry and biophysics Volume: 507 ISSN: 1096-0384 ISO Abbreviation: Arch. Biochem. Biophys. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372430 Medline TA: Arch Biochem Biophys Country: United States |
Other Details:
|
Languages: eng Pagination: 174-85 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris Descartes, 45 rue des Saints-pères, 75270 Paris Cedex 06, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The paradox of multiplex DNA melting on a surface.
Next Document: LHRH-conjugated lytic peptides directly target prostate cancer cells.