Document Detail

Sulfasalazine in severe rheumatoid arthritis: a study to assess potential correlates of efficacy and toxicity.
MedLine Citation:
PMID:  2863375     Owner:  NLM     Status:  MEDLINE    
Thirty-one patients with chronic active rheumatoid arthritis (RA) resistant to gold and/or penicillamine therapy, were treated with sulfasalazine, 2-3 g daily, in a 12-week open study. Nineteen patients completed the study, and of these, 13 showed clinical improvement. Twelve patients were withdrawn from the study because of nausea (8), mouth ulcers (1), disease flare (1) and noncompliance (2). There was no significant difference in serum sulfasalazine concentrations among responders, nonresponders and patients who were withdrawn. Our data suggest that sulfasalazine may be of benefit in the treatment of RA. Further studies are necessary to determine if toxicity and/or efficacy might be related to serum concentrations of sulfasalazine metabolites.
L Martin; D S Sitar; I M Chalmers; T Hunter
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  12     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-10-22     Completed Date:  1985-10-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  270-3     Citation Subset:  IM    
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MeSH Terms
Arthritis, Rheumatoid / blood,  drug therapy*,  physiopathology
Blood Sedimentation
Clinical Trials as Topic
Middle Aged
Sulfasalazine / adverse effects,  blood,  therapeutic use*
Reg. No./Substance:

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